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271012

Sigma-Aldrich

N,N-Dimethylacetamide

anhydrous, 99.8%

Synonym(s):

DMAc

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About This Item

Linear Formula:
CH3CON(CH3)2
CAS Number:
127-19-5
Molecular Weight:
87.12
Beilstein/REAXYS Number:
1737614
EC Number:
204-826-4
MDL number:
MFCD00008686
UNSPSC Code:
12352111
PubChem Substance ID:
57648218
NACRES:
NA.21
grade:
anhydrous
assay:
99.8%
bp:
164.5-166 °C (lit.)
vapor pressure:
2 mmHg ( 25 °C)
4 mmHg ( 38 °C)
Pricing and availability is not currently available.

grade

anhydrous

Quality Level

200

vapor density

3 (vs air)

vapor pressure

2 mmHg ( 25 °C)
4 mmHg ( 38 °C)

assay

99.8%

form

liquid

autoignition temp.

914 °F

expl. lim.

1.8 %, 100 °F
11.5 %, 160 °F

impurities

<0.005% water

evapn. residue

<0.001%

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Application

N,N-Dimethylacetamide may be used as a solvent in the following processes:
  • Palladium (II) acetate-butyldi-1-adamantylphosphine catalyzed arylation of 2-isobutylthiazole with chlorobenzene to form 5-phenyl-2-isobutylthiazole.[1]
  • Synthesis of β-, γ-, and δ-metallo ester intermediates that can react with acid chlorides to form γ-, δ-, and ε-keto esters.[2]
  • Synthesis of (R)-(-)-methyl 1,1′-binaphthyl-2,2′-diylphosphate that can be used as a precursor for preparing (R)-(+)-1,1′-binaphthalene-2,2′-diol.[3]

Packaging

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Other Notes

The article number 271012-4X2L will be discontinued. Please order the single bottle 271012-2L which is physically identical with the same exact specifications.

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pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Eye Irrit. 2 - Repr. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 2

flash_point_f

147.2 °F - closed cup

flash_point_c

64 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

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Certificates of Analysis (COA)

Lot/Batch Number
SHBS4461
SHBR7664
SHBR8797
SHBS2820
SHBS0778

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Ethyl 5-oxo-6-methyl-6-heptenoate from methacryloyl chloride and ethyl 4-iodobutyrate
Yoshinao T, et al
Organic Syntheses, 67, 98-98 (1989)
Density and Viscosity Measurements for Binary Mixtures of 1-Ethyl-3-methylimidazolium Tetrafluoroborate ([Emim][BF4]) with Dimethylacetamide, Dimethylformamide, and Dimethyl Sulfoxide.
Fan XH, et al.
Journal of Chemical and Engineering Data (2016)
(R)-(+)-1,1'-Binaphthalene-2,2'-diol
Truesdale LK
Organic Syntheses, 67, 13-13 (1989)
Solutions of cellulose in N, N-dimethylacetamide/lithium chloride studied by light scattering methods.
Roder T, et al.
Polymer, 42(16), 6765-6773 (2001)
André H Gröschel et al.
Nature communications, 3, 710-710 (2012-03-20)
Hierarchical self-assembly offers elegant and energy-efficient bottom-up strategies for the structuring of complex materials. For block copolymers, the last decade witnessed great progress in diversifying the structural complexity of solution-based assemblies into multicompartment micelles. However, a general understanding of what
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