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Potassium clavulanate

VETRANAL®, analytical standard

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Synonym(s):
Clavulanate potassium
Empirical Formula (Hill Notation):
C8H8NO5K
CAS Number:
Molecular Weight:
237.25
EC Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

analytical standard

Quality Level

product line

VETRANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

agriculture
clinical
environmental
forensics and toxicology
pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

[K+].[H][C@@]12CC(=O)N1[C@@H](C([O-])=O)C(\O2)=C\CO

InChI

1S/C8H9NO5.K/c10-2-1-4-7(8(12)13)9-5(11)3-6(9)14-4;/h1,6-7,10H,2-3H2,(H,12,13);/q;+1/p-1/b4-1-;/t6-,7-;/m1./s1

InChI key

ABVRVIZBZKUTMK-JSYANWSFSA-M

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General description

Potassium clavulanate is an oxapenam derivative and belongs to the group of β-lactamase inhibitors. It is used in combination with the penicillin group of antibiotics to give them resistance to β-lactamase.

Application

The analytical standard can be used as follows:
  • Simultaneous analysis of amoxicillin and clavulanate potassium in pharmaceutical formulations by capillary electrophoresis (CE) combined with capacitively coupled contactless conductivity detection (C4D)
  • Development of a stability-indicating high-performance liquid chromatographic (HPLC) method combined with mass spectrometry (MS) to measure amoxicillin, clavulanate potassium, and their impurities in their combined dosage forms
  • Residue analysis of potassium clavulanate and amoxicillin trihydrate by a UV spectrophotometric method in their bulk, combined tablet formulations, and human urine samples
  • HPLC method-based determination of meropenem and potassium clavulanate in the presence of their degradation impurities in intravenous solutions in combination with a diode array detector (DAD)
  • Determination of amoxicillin and clavulanic acid by capillary zone electrophoresis (CZE) in their combined commercial formulations

Biochem/physiol Actions

β-lactamase inhibitor, typically added to amoxicillin to increase its effectiveness.

Other Notes

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

FlameHealth hazard

signalword

Danger

Hazard Classifications

Flam. Sol. 2 - Resp. Sens. 1 - Self-heat. 2 - Skin Sens. 1

supp_hazards

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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David Baunoch et al.
Infection and drug resistance, 14, 3275-3286 (2021-08-28)
Studies have shown that multiple genes influence antibiotic susceptibility, but the relationship between genotypic and phenotypic antibiotic susceptibility is unclear. We sought to analyze the concordance between the presence of antibiotic resistance (ABR) genes and antibiotic susceptibility results in urine
Yoram Fleissig et al.
Oral surgery, oral medicine, oral pathology and oral radiology, 113(3), e1-e3 (2012-06-09)
A 58-year-old woman presented to the Oral and Maxillofacial Surgery Clinic experiencing severe limited mouth opening and exposed bone in the socket of the right mandibular third molar 8 months following the extraction of the tooth. The patient had been
B R Smith et al.
Drug intelligence & clinical pharmacy, 19(6), 415-420 (1985-06-01)
Potassium clavulanate is a novel beta-lactamase inhibitor, which, in combination, expands the spectrum of amoxicillin to include many amoxicillin-resistant organisms. Potassium clavulanate is excreted 30-50 percent unchanged renally and its plasma time-course parallels that of amoxicillin. Several studies suggest that
Marisa L Winkler et al.
Journal of medicinal chemistry, 56(3), 1084-1097 (2012-12-21)
Inhibitor resistant (IR) class A β-lactamases pose a significant threat to many current antibiotic combinations. The K234R substitution in the SHV β-lactamase, from Klebsiella pneumoniae , results in resistance to ampicillin/clavulanate. After site-saturation mutagenesis of Lys-234 in SHV, microbiological and
Dejenie Shiferaw Teklu et al.
Antimicrobial resistance and infection control, 8, 39-39 (2019-03-01)
The global emergence and spread of extended-spectrum beta-lactamases (ESBLs) producing Enterobacteriaceae have been threatening the ability to treat an infection. Hence, this study aimed to determine the prevalence of ESBL-producing and multi-drug resistance (MDR) Enterobacteriaceae (ESBLs-E) from different clinical specimens

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