MilliporeSigma
All Photos(3)

Documents

402885

Sigma-Aldrich

p-Toluenesulfonic acid monohydrate

ACS reagent, ≥98.5%

Sign Into View Organizational & Contract Pricing

Synonym(s):
4-Methylbenzenesulfonic acid monohydrate, 4-Toluenesulfonic acid monohydrate, PTSA monohydrate, TsOH monohydrate
Linear Formula:
CH3C6H4SO3H · H2O
CAS Number:
Molecular Weight:
190.22
Beilstein:
3568023
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.21

grade

ACS reagent

Quality Level

vapor density

5.9 (vs air)

Assay

≥98.5%

form

solid

clarity of soln

passes test

impurities

9.5-11.5% water

ign. residue

≤0.1%

mp

103-106 °C (lit.)

solubility

H2O: 10g + 50 mL, clear, colorless

anion traces

sulfate (SO42-): ≤0.3%

cation traces

Fe: ≤0.01%
Na: ≤0.002%
heavy metals (as Pb): ≤0.001%

SMILES string

[H]O[H].Cc1ccc(cc1)S(O)(=O)=O

InChI

1S/C7H8O3S.H2O/c1-6-2-4-7(5-3-6)11(8,9)10;/h2-5H,1H3,(H,8,9,10);1H2

InChI key

KJIFKLIQANRMOU-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

Related Categories

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
27815T35920PHR2495
Lisinopril Impurity B Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR2495

Lisinopril Impurity B

vapor density

5.9 (vs air)

vapor density

-

vapor density

5.9 (vs air)

vapor density

5.9 (vs air)

assay

≥98.5%

assay

≥99% (calc. to H2O free subst.)

assay

≥98%

assay

-

form

solid

form

solid

form

-

form

powder

impurities

9.5-11.5% water

impurities

≥85% toluene-4-solfonic acid, 8-12% water (Karl Fischer)

impurities

-

impurities

-

mp

103-106 °C (lit.)

mp

-

mp

103-106 °C (lit.)

mp

103-106 °C (lit.)

General description

p-Toluenesulfonic acid monohydrate, an oxonium salt, is an inexpensive and easy to handle organic catalyst used in organic synthesis. The study of its crystalline structure shows that it is monoclinic with P21/c space group. Its solubility in aqueous sulfuric acid solutions has been studied.

Application

p-Toluenesulfonic acid monohydrate (p-TsOH·H2O) may be used as a catalyst in the synthesis of the following:
  • Unsymmetrical benzils.
  • Highly substituted piperidines.
  • 1,3,5-Trisubstituted benzenes by trimerization of alkynes.
  • Triazoloquinazolinone and benzimidazoquinazolinone derivatives.
  • 1,3,5-Trisubstituted pyrazoles derivatives.
  • Selenated ketene dithioacetals.

Pictograms

CorrosionExclamation mark

Signal Word

Danger

Hazard Statements

Hazard Classifications

Aquatic Chronic 3 - Eye Dam. 1 - Met. Corr. 1 - Skin Corr. 1C - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

8A - Combustible, corrosive hazardous materials

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Documents related to the products that you have purchased in the past have been gathered in the Document Library for your convenience.

Visit the Document Library

Difficulty Finding Your Product Or Lot/Batch Number?

Product numbers are combined with Pack Sizes/Quantity when displayed on the website (example: T1503-25G). Please make sure you enter ONLY the product number in the Product Number field (example: T1503).

Example:

T1503
Product Number
-
25G
Pack Size/Quantity

Additional examples:

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

enter as 1.000309185)

Having trouble? Feel free to contact Technical Service for assistance.

Lot and Batch Numbers can be found on a product's label following the words 'Lot' or 'Batch'.

Aldrich Products

  • For a lot number such as TO09019TO, enter it as 09019TO (without the first two letters 'TO').

  • For a lot number with a filling-code such as 05427ES-021, enter it as 05427ES (without the filling-code '-021').

  • For a lot number with a filling-code such as STBB0728K9, enter it as STBB0728 without the filling-code 'K9'.

Not Finding What You Are Looking For?

In some cases, a COA may not be available online. If your search was unable to find the COA you can request one.

Request COA

Customers Also Viewed

Slide 1 of 2

1 of 2

Catalytic systems containing p-toluenesulfonic acid monohydrate catalyzed the synthesis of triazoloquinazolinone and benzimidazoquinazolinone derivatives.
Mousavi MR and Maghsoodlou MT.
Monatshefte fur Chemie / Chemical Monthly, 145(12), 1967-1973 (2014)
One-pot multicomponent synthesis of highly substituted piperidines using p-toluenesulfonic acid monohydrate as catalyst.
Sajadikhah SS, et al.
Monatshefte fur Chemie / Chemical Monthly, 143(6), 939-945 (2012)
Solubilities of p-Toluenesulfonic Acid Monohydrate and Sodium p-Toluenesulfonate in Aqueous Sulfuric Acid Solutions and Its Application for Preparing Sodium p-Toluenesulfonate.
Zhao W, et al.
Industrial & Engineering Chemistry Research, 52(51), 18466-18471 (2013)
One-pot synthesis of unsymmetrical benzils from aryl methyl ketones and arenes in the presence of selenous acid catalysed by p-toluenesulfonic acid monohydrate.
Kharkongor I, et al.
Tetrahedron Letters, 53(23), 2837-2841 (2012)
Br?nsted acid-catalyzed phenylselenenylation of internal olefins.
Wu P, et al.
Tetrahedron Letters, 56(19), 2488-2491 (2015)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service