43729

1-Methyl-2-pyrrolidinone

for metal speciation analysis, ≥99.0% (GC)

• Synonym(s): 1-Methyl-2-pyrrolidone, N-Methyl-2-pyrrolidone, NMP
• Empirical Formula (Hill Notation): C₅H₉NO
• CAS Number: 872-50-4
• Molecular Weight: 99.13
• Beilstein/REAXYS Number: 106420
• EC Number: 212-828-1
• MDL number: MFCD00003193
• UNSPSC Code: 41116105
• PubChem Substance ID: 329756383
• NACRES: NA.24

Properties

• vapor density: 3.4 (vs air)
• vapor pressure: 0.29 mmHg ( 20 °C); 0.99 mmHg ( 40 °C)
• assay: ≥99.0% (GC)
• autoignition temp.: 518 °F
• quality: for metal speciation analysis
• expl. lim.: 9.5 %
• impurities: ≤0.1% water
• refractive index: n20/D 1.47 (lit.); n20/D 1.470
• bp: 202 °C (lit.); 81-82 °C/10 mmHg (lit.)
• mp: −24 °C (lit.)

Description

General description

NMP is an effective solvent for organic and inorganic compounds. Tertiary amides in H-bond basicity are decreased by bulky substituents on carbon than bulky substituents on nitrogen. It is also an effective solvent for the decarbonylation of aldehydes. It exhibits as reagent and amidines formed from NMP exist as amidine-enediamine tautomers. As cosolvent it has ability to enhance the reactivity of other reagents.

Application

NMP was used:

• as an aqueous physical solvent to measure the molar heat capacities.
• in the synthesis of Nafion/SiO2 nanocomposite membranes.
• in the synthesis of N-Butyl-N,N-dimethyl chitosan iodide (QCh).
• as an inducer to demonstrate phenotypic resistance to Chloramphenicol and ampicillin in Escherichia coli K-12 starins.
• used as polar solvent inducer for erythroleukemic cell differentiation.
• as a blocking reagent in microarray manufacturing.

Safety Information

• pictograms: GHS08,GHS07
• signalword: Danger
• hcodes: H315,H319,H335,H360D
• pcodes: P202 - P261 - P264 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk_germany: WGK 1
• flash_point_f: 195.8 °F - Pensky-Martens closed cup
• flash_point_c: 91 °C - Pensky-Martens closed cup
• ppe: Eyeshields, Gloves, type ABEK (EN14387) respirator filter