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484407

Sigma-Aldrich

1-Methoxy-2-propanol

greener alternative

≥99.5%

Synonym(s):
Propylene glycol methyl ether, Propyleneglycol monomethyl ether
Linear Formula:
CH3CH(OH)CH2OCH3
CAS Number:
Molecular Weight:
90.12
Beilstein:
1731270
EC Number:
MDL number:
PubChem Substance ID:

vapor density

3.12 (vs air)

Quality Level

vapor pressure

10.9 mmHg ( 25 °C)

product line

ReagentPlus®

Assay

≥99.5%

form

liquid

autoignition temp.

532 °F

expl. lim.

13.8 %

greener alternative product characteristics

Safer Solvents and Auxiliaries
Learn more about the Principles of Green Chemistry.

impurities

≤0.001% water

refractive index

n20/D 1.403 (lit.)

bp

118-119 °C (lit.)

mp

-97 °C

solubility

water: miscible

density

0.916 g/mL at 25 °C (lit.)

application(s)

microbiology

greener alternative category

SMILES string

CC(O)COC

InChI

1S/C4H10O2/c1-4(5)3-6-2/h4-5H,3H2,1-2H3

InChI key

ARXJGSRGQADJSQ-UHFFFAOYSA-N

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1 of 4

This Item
656921.16738484431
1-Methoxy-2-propanol ≥99.5%

Sigma-Aldrich

484407

1-Methoxy-2-propanol

1-Methoxy-2-propanol analytical standard

Supelco

65692

1-Methoxy-2-propanol

1-Methoxy-2-propanol EMPLURA®

Supelco

1.16738

1-Methoxy-2-propanol

vapor pressure

10.9 mmHg ( 25 °C)

vapor pressure

10.9 mmHg ( 25 °C)

vapor pressure

11.5 hPa ( 20 °C)

vapor pressure

3.7 mmHg ( 20 °C)

assay

≥99.5%

assay

≥99.7% (GC)

assay

≥99.5%

assay

≥99.5%

form

liquid

form

-

form

liquid

form

-

autoignition temp.

532 °F

autoignition temp.

532 °F

autoignition temp.

287 °C

autoignition temp.

669 °F

expl. lim.

13.8 %

expl. lim.

13.8 %

expl. lim.

1.7-11.5 % (v/v)

expl. lim.

13.1 %

General description

1-Methoxy-2-propanol (Propylene glycol methyl ether, PGME), a glycol ether, can be synthesized by reacting propylene oxide with methanol in the presence of ZnMgAl (zinc-magnesium-aluminium) catalysts. Its degradation by microorganisms in different soil types has been investigated. An oral reference dose (RfD) and an inhalation reference concentration (RfC) values of PGME have been obtained from inhalation studies in F344 rats and B6C3F1 mice.
We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Green Chemistry.Monoethers, especially propylene glycol methyl ether (PGME), are widely used as pollution-free solvents in fine chemical synthesis in pharmaceutical, chemical and cosmetic industries and thus aligns with "Safer Solvents and Auxiliaries". Click here for more information.

Legal Information

ReagentPlus is a registered trademark of Sigma-Aldrich Co. LLC

Pictograms

FlameExclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Flam. Liq. 3 - STOT SE 3

Target Organs

Central nervous system

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Flash Point(F)

93.2 °F - closed cup

Flash Point(C)

34 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Customers Also Viewed

Slide 1 of 2

1 of 2

Influence of acid-base properties of ZnMgAl-mixed oxides for the synthesis of 1-methoxy-2-propanol.
Cheng W, et al.
Applied Clay Science, 42(1), 111-115 (2008)
Biodegradation of glycol ethers in soil.
Gonsior SJ and West RJ.
Environmental Toxicology and Chemistry / Setac, 14(8), 1273-1279 (1995)
Rei Momose et al.
Organic letters, 15(8), 2010-2013 (2013-04-11)
Three new alkaloids, hyrtimomines A-C (1-3), were isolated from an Okinawan marine sponge Hyrtios sp. The structures of 1-3 were elucidated on the basis of spectroscopic analysis and application of a phenylglycine methyl ester (PGME) method. Hyrtimomines A (1) and
C R Kirman et al.
Risk analysis : an official publication of the Society for Risk Analysis, 25(2), 271-284 (2005-05-07)
Reference values, including an oral reference dose (RfD) and an inhalation reference concentration (RfC), were derived for propylene glycol methyl ether (PGME), and an oral RfD was derived for its acetate (PGMEA). These values were based on transient sedation observed
Juergen Brieger et al.
Toxicology letters, 177(2), 138-143 (2008-02-26)
To evaluate the impact of 1-methoxypropanol-2 (MEP) for the stimulation of an inflammatory response in human respiratory mucosa, we exposed 22 primary cell cultures of nasal respiratory epithelia of healthy individuals to MEP concentrations at the level of the German

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