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Methacryloyl chloride

purum, dist., ≥97.0% (GC), contains ~0.02% 2,6-di-tert-butyl-4-methylphenol as stabilizer

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2-Methylprop-2-enoyl chloride, Methacrylic acid chloride, Methacrylyl chloride
Linear Formula:
CAS Number:
Molecular Weight:
EC Number:
MDL number:
PubChem Substance ID:



Quality Level


≥97.0% (GC)




~0.02% 2,6-di-tert-butyl-4-methylphenol as stabilizer


≤1000 mg/kg total sulfur (as SO4)

refractive index

n20/D 1.442 (lit.)
n20/D 1.444


95-96 °C (lit.)


1.08 g/mL at 20 °C
1.07 g/mL at 25 °C (lit.)

storage temp.


SMILES string




InChI key


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General description

Methacryloyl chloride is the acid chloride of methacrylic acid that is used in the field of polymers as a monomer or a reactive intermediate in the synthesis of various polymers. It is used to synthesize various polymers, such as poly(methacryloyl chloride), poly(methacrylates), and poly(methacrylamides) for wide applications including the production of dental materials, adhesives, contact lenses, hydrogels, coatings, and in the development of various biomedical devices.


Methacryloyl chloride can be used as:
  • A monomer in the synthesis of amphiphilic fluorescent copolymers via reversible addition-fragmentation chain transfer (RAFT) polymerization. The resulting copolymers have smart pH sensitivity and fluorescence properties, which make them suitable for use in cell imaging.
  • A monomer in the emulsion polymerization process to prepare a fluorescence probe, which is used for the detection of metronidazole.
  • A surface modifier for microcrystalline cellulose (MCC) to improve its compatibility with low-density polyethylene (LDPE) in the preparation of LDPE-based composites.
  • A key component in the synthesis of carboxymethyl cellulose acrylates, which find applications in the development of pH-sensitive hydrogels.
  • A monomer in the synthesis of methacrylate-based hydrogel materials, which are widely used in the production of soft contact lenses.
Methacryloyl chloride can also be used:
  • To prepare methacryloyl-functional benzoxazine monomer.
  • As a precursor to prepare N-methacryloyl-(L)-histidinemethylester(MAH), a metal chelating monomer.

Signal Word


Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B - Skin Sens. 1

Storage Class Code

3 - Flammable liquids



Flash Point(F)

55.0 °F - closed cup

Flash Point(C)

12.8 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Xiangzheng Hu et al.
Steroids, 70(8), 531-537 (2005-05-17)
Bile acids in the family of steroid compounds can be chemically modified for biochemical and other applications. Derivatives of cholic acid with multiple methacrylate groups can be prepared by the use of methacrylic acid, methacryloyl chloride and methacryloyl anhydride as
E Asmussen et al.
Scandinavian journal of dental research, 91(2), 153-155 (1983-04-01)
The bonding of restorative resins to dentin by means of an intermediary monomer containing a carboxylic acid chloride or an isocyanate group was investigated. Such intermediary monomers are supposed to react with the organic constituent of dentin. Bond strengths were
Runhai Chen et al.
Macromolecular bioscience, 20(2), e1900331-e1900331 (2019-12-20)
Polymer nanoparticulate drug delivery systems that respond to reactive oxygen species (ROS) and glutathione (GSH) simultaneously at biologically relevant levels hold great promise to improve the therapeutic efficacy to cancer cells with reduced side effects of chemo drugs. Herein, a
Polymerized phosphatidyl choline vesicles. Stabilized and controllable time-release carriers.
S L Regen et al.
Biochemical and biophysical research communications, 101(1), 131-136 (1981-07-16)
Jinghui Li et al.
Scientific reports, 7, 40082-40082 (2017-01-05)
Crosslinking is an effective way to fabricate high-selective CO

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