91503

Palmitoyl-L-carnitine

analytical standard

• Synonym(s): (2R)-3-Carboxy-N,N,N-trimethyl-2-[(1-oxohexadecyl)oxy]-1-propanaminium inner salt, L-Carnitine hexadecanoyl ester, C16-Carnitine, Hexadecanoyl-L-carnitine
• Empirical Formula (Hill Notation): C₂₃H₄₅NO₄
• CAS Number: 2364-67-2
• Molecular Weight: 399.61
• Beilstein/REAXYS Number: 4152034
• UNSPSC Code: 41116107
• NACRES: NB.21

Properties

• grade: analytical standard
• Quality Level: 100
• assay: ≥95.0% (HPLC)
• optical activity: [α]/D -17.0±2.0°, c = 1 in methanol
• shelf life: limited shelf life, expiry date on the label
• impurities: ≤10% water
• application(s): clinical testing
• format: neat
• storage temp.: 2-8°C
• SMILES string: C[N+](C)(C)C[C@H](OC(CCCCCCCCCCCCCCC)=O)CC([O-])=O
• InChI: 1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m1/s1
• InChI key: XOMRRQXKHMYMOC-OAQYLSRUSA-N

Description

General description

Palmitoyl-L-carnitine (PLC) belongs to the class of long chain acylcarnitine compounds. It is an acyl-chain ester, which can be obtained from L-carnitine via acylcarnitine family transferase. PLC is reported to be used for the phospholipid reacylation in erythrocyte membrane ghosts.

Application

Palmitoyl-L-carnitine may be used as an analytical standard to quantify the analyte in biological samples of patients with continuous ambulatory peritoneal dialysis (CAPD) or automated peritoneal dialysis (APD) using high-performance liquid chromatography/tandem quadrupole mass spectrometry (HPLC-TQMS). The feasibility of adding L-carnitine to the peritoneal dialysis (PD) solution in APD-treated end-stage renal disease patients is investigated. It may also be used as an analytical reference standard for the separation and identification of underivatized palmitoyl-L-carnitine in human plasma samples using high-performance liquid chromatography coupled to tandem mass spectrometry (HPLC-MS/MS).

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Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable