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P9672

Supelco

Probucol

analytical standard

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About This Item

Empirical Formula (Hill Notation):
C31H48O2S2
CAS Number:
Molecular Weight:
516.84
EC Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

analytical standard

Quality Level

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

SMILES string

CC(C)(C)c1cc(SC(C)(C)Sc2cc(c(O)c(c2)C(C)(C)C)C(C)(C)C)cc(c1O)C(C)(C)C

InChI

1S/C31H48O2S2/c1-27(2,3)21-15-19(16-22(25(21)32)28(4,5)6)34-31(13,14)35-20-17-23(29(7,8)9)26(33)24(18-20)30(10,11)12/h15-18,32-33H,1-14H3

InChI key

FYPMFJGVHOHGLL-UHFFFAOYSA-N

Gene Information

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This Item
926156938968436
grade

certified reference material, TraceCERT®

grade

certified reference material, TraceCERT®

grade

certified reference material, TraceCERT®

grade

certified reference material, TraceCERT®

format

single component solution

format

single component solution

format

single component solution

format

single component solution

concentration

1 mg/L Sn in nitric acid and hydrofluoric acid (nominal concentration)

concentration

1 g/L Sn in hydrochloric acid (nominal concentration)

concentration

1 mg/L Ag in nitric acid (nominal concentration)

concentration

1 mg/L Fe in nitric acid (nominal concentration)

product line

TraceCERT®

product line

TraceCERT®

product line

TraceCERT®

product line

TraceCERT®

application(s)

industrial qc
pharmaceutical

application(s)

industrial qc
pharmaceutical

application(s)

industrial qc
pharmaceutical

application(s)

industrial qc
pharmaceutical

General description

Probucol is a diphenolic compound possessing antioxidant and anti-inflammatory properties.[1] It is commercially used as a lipid lowering drug, which helps in reducing the total plasma cholesterol, low density lipoprotein cholesterol (LDL) and high density lipoprotein cholesterol (HDL).[2]

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Enhances selective uptake of HDL-associated cholesteryl esters.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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    Jonathan Watt et al.
    Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 81(4), 698-708 (2012-05-15)
    The aim of this study was to assess the efficacy of stent-based delivery of succinobucol alone and in combination with rapamycin in a porcine coronary model. Current drugs and polymers used to coat coronary stents remain suboptimal in terms of
    Eduardo Luiz Gasnhar Moreira et al.
    Neuroscience letters, 541, 193-198 (2013-03-09)
    Epidemiological studies indicate that high midlife plasma cholesterol levels increases the risk of Alzheimer's disease. Moreover, middle-aged familial hypercholesterolemia (FH) subjects show a particularly high incidence of mild cognitive impairments (MCI). These evidence points to hypercholesterolemia as one of the
    Chang-Jiang Ge et al.
    Chinese medical journal, 125(14), 2472-2476 (2012-08-14)
    The plasma cystatin C concentration (PcyC) has been demonstrated to have prognostic value in acute coronary syndrome, but the study of PcyC in patients with borderline coronary lesions is limited. Moreover, the effects of atorvastatin and probucol on PcyC and
    Zhiwen Zhang et al.
    International journal of pharmaceutics, 444(1-2), 162-168 (2013-01-24)
    The therapeutic efficacy of lipophilic drugs is commonly restricted by the low systemic exposure after oral administration. In this work, a new delivery system combining the advantages of porous starch and self-assembled nanocarrier was designed to improve the oral absorption
    Shao-Bin Duan et al.
    Renal failure, 34(10), 1244-1251 (2012-09-27)
    To elucidate the relationship of oxidative stress and specificity protein 1 (Sp1) in the process of epithelial-to-mesenchymal transdifferentiation (EMT) and also to investigate the molecular mechanism of protective effect of probucol on the pathogenesis of diabetic kidney disease (DKD). Thirty

    Articles

    Lipoproteins package cholesterol for transport in plasma, essential for lipid transport and cellular function in the body.

    Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

    Contact Technical Service