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PHR1006

Supelco

Sorbitol

Pharmaceutical Secondary Standard; Certified Reference Material

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Synonym(s):
D-Sorbitol, D-Glucitol
Empirical Formula (Hill Notation):
C6H14O6
CAS Number:
Molecular Weight:
182.17
Beilstein:
1721899
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

Agency

traceable to Ph. Eur. S100000
traceable to USP 1617000

vapor density

<1 (vs air)

vapor pressure

<0.1 mmHg ( 25 °C)

API family

sorbitol

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

98-100 °C (lit.)

application(s)

cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care
pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)CO

InChI

1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1

InChI key

FBPFZTCFMRRESA-JGWLITMVSA-N

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Sorbitol Pharmaceutical Secondary Standard; Certified Reference Material

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PHR1006

Sorbitol

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PHR2558

1,4-Sorbitan

Glycerin Pharmaceutical Secondary Standard; Certified Reference Material

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PHR1020

Glycerin

Fructose Pharmaceutical Secondary Standard; Certified Reference Material

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PHR1002

Fructose

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

-

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care
pharmaceutical (small molecule)

application(s)

-

application(s)

cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care
pharmaceutical (small molecule)

application(s)

cleaning products
cosmetics
food and beverages
personal care
pharmaceutical (small molecule)

format

neat

format

-

format

neat

format

neat

storage temp.

2-30°C

storage temp.

2-30°C

storage temp.

2-30°C

storage temp.

2-30°C

Quality Level

300

Quality Level

300

Quality Level

300

Quality Level

300

General description

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to pharmacopeia primary standards

Application

Sorbitol may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by high performance liquid chromatography technique.
Sorbitol may be used as an internal standard in the quantitative determination ofD-glucose in corn sugar and corn syrups using gas liquid chromatography (GLC).
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB7795 in the slot below. This is an example certificate only and may not be the lot that you receive.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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Sigma-Aldrich

97336

D-Sorbitol

Sorbitol F solution 70&#160;wt. % in H2O, Contains mainly D-sorbitol with lesser amounts of other hydrogenated oligosaccharides

Sigma-Aldrich

309532

Sorbitol F solution

Maltitol &#8805;98%

Sigma-Aldrich

M8892

Maltitol

Sorbitol liquid, (sorbitol syrup, crystallizing), EMPROVE&#174; ESSENTIAL, Ph. Eur., BP, USP, E 420

SAFC

1.02994

Sorbitol

D(-)-Sorbitol extra pure, suitable for microbiology

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D(-)-Sorbitol

Dextrose Pharmaceutical Secondary Standard; Certified Reference Material

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PHR1000

Dextrose

Use of sorbitol as internal standard in determination of D-glucose by gas liquid chromatography
Alexander.J.R and Garbutt.T.J
Analytical Chemistry, 37, 303-305 (1965)
An isocratic HPLC method for the determination of sorbitol and glycerol in pharmaceutical formulations
Simonzadeh N and Ronsen B
Journal of Chromatographic Science, 50(7), 644-647 (2012)
Determination of nimesulide in pharmaceutical dosage forms by second order derivative UV spectrophotometry
Altinoz S and Dursun OO
Journal of Pharmaceutical and Biomedical Analysis, 22(1), 175-182 (2000)
G Molino et al.
The Journal of laboratory and clinical medicine, 131(5), 393-405 (1998-05-30)
D-Sorbitol (SOR) is safe, is easy to measure, and has an exceptionally high extraction ratio in the normal liver of 0.93+/-0.05 (mean+/-SD). Together with the general interest in hepatic hemodynamics, these facts motivated us to review the usefulness of this
Arlene E Dent et al.
PloS one, 3(10), e3557-e3557 (2008-10-30)
Antibodies that impair Plasmodium falciparum merozoite invasion and intraerythrocytic development are one of several mechanisms that mediate naturally acquired immunity to malaria. Attempts to correlate anti-malaria antibodies with risk of infection and morbidity have yielded inconsistent results. Growth inhibition assays

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