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PHR1042

Supelco

Prednisone

Pharmaceutical Secondary Standard; Certified Reference Material

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Synonym(s):
1,4-Pregnadiene-17α,21-diol-3,11,20-trione, 1-Cortisone, 17α,21-Dihydroxy-1,4-pregnadiene-3,11,20-trione, Dehydrocortisone
Empirical Formula (Hill Notation):
C21H26O5
CAS Number:
Molecular Weight:
358.43
Beilstein/REAXYS Number:
2065301
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

agency

traceable to BP 553
traceable to Ph. Eur. P2900000
traceable to USP 1559006

API family

prednisone

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

236-238 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

O=C1C=C[C@@]2(C)C(CC[C@]([C@@](CC[C@@]3(C(CO)=O)O)([H])[C@]3(C)C4)([H])[C@]2([H])C4=O)=C1

InChI

1S/C21H26O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-15,18,22,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1

InChI key

XOFYZVNMUHMLCC-ZPOLXVRWSA-N

Gene Information

human ... NR3C1(2908)

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This Item
P29000001559006BP553
Prednisone Pharmaceutical Secondary Standard; Certified Reference Material

PHR1042

Prednisone

Prednisone European Pharmacopoeia (EP) Reference Standard

P2900000

Prednisone

Prednisone United States Pharmacopeia (USP) Reference Standard

1559006

Prednisone

Prednisone British Pharmacopoeia (BP) Reference Standard

BP553

Prednisone

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical

format

neat

format

neat

format

neat

format

neat

Quality Level

300

Quality Level

-

Quality Level

-

Quality Level

-

grade

certified reference material, pharmaceutical secondary standard

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

storage temp.

2-30°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Prednisone may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by spectrophotometry and chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA8969 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Health hazard

signalword

Warning

hcodes

pcodes

Hazard Classifications

STOT RE 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Prednisone British Pharmacopoeia (BP) Reference Standard

BP553

Prednisone

Prednisone European Pharmacopoeia (EP) Reference Standard

P2900000

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Budesonide Pharmaceutical Secondary Standard; Certified Reference Material

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Cortisone Acetate Pharmaceutical Secondary Standard; Certified Reference Material

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Prednisone ≥98%

Sigma-Aldrich

P6254

Prednisone

Prednisone United States Pharmacopeia (USP) Reference Standard

USP

1559006

Prednisone

Jörg D Leuppi et al.
JAMA, 309(21), 2223-2231 (2013-05-23)
International guidelines advocate a 7- to 14-day course of systemic glucocorticoid therapy in acute exacerbations of chronic obstructive pulmonary disease (COPD). However, the optimal dose and duration are unknown. To investigate whether a short-term (5 days) systemic glucocorticoid treatment in
Ian F Tannock et al.
The Lancet. Oncology, 14(8), 760-768 (2013-06-08)
Docetaxel plus prednisone is standard first-line chemotherapy for men with metastatic castrate-resistant prostate cancer. Aflibercept is a recombinant human fusion protein that binds A and B isoforms of VEGF and placental growth factor, thereby inhibiting angiogenesis. We assessed whether the
M Dror Michaelson et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 32(2), 76-82 (2013-12-11)
We evaluated angiogenesis-targeted sunitinib therapy in a randomized, double-blind trial of metastatic castration-resistant prostate cancer (mCRPC). Men with progressive mCRPC after docetaxel-based chemotherapy were randomly assigned 2:1 to receive sunitinib 37.5 mg/d continuously or placebo. Patients also received oral prednisone
Ronald de Wit
European journal of cancer (Oxford, England : 1990), 41(4), 502-507 (2005-03-02)
Until now, the use of systemic chemotherapy for advanced androgen-independent prostate cancer has had very little to offer to patients. However, in 2004, two large randomised trials investigating docetaxel vs. mitoxantrone have both demonstrated survival improvements, and, in one of
O Teuffel et al.
Leukemia, 25(8), 1232-1238 (2011-04-30)
This systematic review and meta-analysis compared the efficacy and toxicity of dexamethasone (DEX) versus prednisone (PRED) for induction therapy in childhood acute lymphoblastic leukemia (ALL). We searched biomedical literature databases and conference proceedings for randomized controlled trials comparing DEX and

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