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PHR1331

Supelco

Metformin Related Compound A

Pharmaceutical Secondary Standard; Certified Reference Material

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Synonym(s):
Dicyandiamide, Cyanoguanidine, Dicyanodiamide
Linear Formula:
NH2C(=NH)NHCN
CAS Number:
Molecular Weight:
84.08
Beilstein/REAXYS Number:
605637
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

agency

traceable to USP 1396310

API family

metformin

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

208-211 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

NC(=N)NC#N

InChI

1S/C2H4N4/c3-1-6-2(4)5/h(H4,4,5,6)

InChI key

QGBSISYHAICWAH-UHFFFAOYSA-N

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1 of 4

This Item
PHR1506PHR1505PHR1530
Metformin Related Compound A Pharmaceutical Secondary Standard; Certified Reference Material

PHR1331

Metformin Related Compound A

Supelco

PHR1506

Metformin Related Compound C

Supelco

PHR1505

Metformin Related Compound B

Acetaminophen Related Compound D Pharmaceutical Secondary Standard; Certified Reference Material

PHR1530

Acetaminophen Related Compound D

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

format

neat

format

neat

format

neat

format

neat

Quality Level

300

Quality Level

300

Quality Level

300

Quality Level

300

grade

certified reference material, pharmaceutical secondary standard

grade

certified reference material, pharmaceutical secondary standard

grade

certified reference material, pharmaceutical secondary standard

grade

certified reference material, pharmaceutical secondary standard

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-30°C

General description

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

It is an impurity of the widely used antidiabetic drug, metformin, that belongs to the biguanide class of compounds.

Application

This pharmaceutical secondary standard can also be used as follows:
  • Separation and estimation of metformin along with other antidiabetics from meglitinides class in the presence of metformin impurity cyanoguanidine using a liquid chromatography method in pharmaceutical formulations
  • Development of a reversed phase-high performance liquid chromatographic (RP-HPLC) method combined with a UV-diode array detector (PDA) for the impurity analysis of combined dosage tablet of metformin hydrochloride and teneligliptin hydrobromide hydrate
  • Estimation of empagliflozin, linagliptin, along with metformin and its related impurities cyanoguanidine and melamine using HPLC-DAD and high-performance thin layer chromatography (HPTLC) methods in their combined tablets
  • Development and validation of a stability indicating capillary zone electrophoresis (CZE) method for the quantification of metformin and its major impurity in pharmaceutical formulation
  • Simultaneous determination of vildagliptin, metformin, and metformin-related compounds (A, B, and C) in tablets using a high-performance liquid chromatography-tandem mass spectrometry method (HPLC-MS/MS)

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA0834 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Environment

hcodes

Hazard Classifications

Aquatic Chronic 2

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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USP

USP

1396342

Metformin Related Compound C

Melamine analytical standard

Supelco

52549

Melamine

Metformin hydrochloride European Pharmacopoeia (EP) Reference Standard

M0605000

Metformin hydrochloride

A new rapid and economic liquid chromatographic method for simultaneous determination of meglitinides with metformin: application in the presence of metformin and repaglinide impurities and related compounds
El-Zaher AA, et al.
Journal of the Iranian Chemical Society, 15, 61-74 (2018)
Impurity profiling method development and validation of metformin hydrochloride and teneligliptin hydrobromide hydrate in their combination tablet dosage form by using RP-HPLC with UV/PDA detector
Musmade BD, et al.
Future Journal of Pharmaceutical Sciences, 7, 1-10 (2021)
HPLC-MS/MS method for simultaneous quantification of vildagliptin, metformin, and metformin-related compounds in tablets
Uber CP, et al.
International Journal of Pharmacy and Pharmaceutical Sciences, 6, 203-207 (2014)
Green chromatographic methods for simultaneous micro-determination of empagliflozin, linagliptin with metformin and its pharmacopoeial impurities in pure form and triple combination tablets: A comparative study
El-Kafrawy DS, et al.
Sustainable Chemistry and Pharmacy, 25, 100560-100560 (2022)
Changkyu Kim et al.
Nanoscale, 7(15), 6627-6635 (2015-03-21)
The realization of air-stable nanoparticles, well-formulated nanoinks, and conductive patterns based on copper is a great challenge in low-cost and large-area flexible printed electronics. This work reports the synthesis of a conductively interconnected copper structure via thermal sintering of copper

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