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PHR1391

Supelco

Praziquantel

Pharmaceutical Secondary Standard; Certified Reference Material

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Synonym(s):
Praziquantel, 2-(Cyclohexylcarbonyl)-1,2,3,6,7-11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one
Empirical Formula (Hill Notation):
C19H24N2O2
CAS Number:
Molecular Weight:
312.41
Beilstein:
761557
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

Agency

traceable to Ph. Eur. P2670000
traceable to USP 1554603

API family

praziquantel

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

O=C1CN(CC2N1CCc3ccccc23)C(=O)C4CCCCC4

InChI

1S/C19H24N2O2/c22-18-13-20(19(23)15-7-2-1-3-8-15)12-17-16-9-5-4-6-14(16)10-11-21(17)18/h4-6,9,15,17H,1-3,7-8,10-13H2

InChI key

FSVJFNAIGNNGKK-UHFFFAOYSA-N

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This Item
46648PHR1691PHR2963
Praziquantel Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1391

Praziquantel

Praziquantel VETRANAL®, analytical standard

Supelco

46648

Praziquantel

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

-

application(s)

pharmaceutical (small molecule)

application(s)

clinical testing

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical

format

neat

format

neat

format

neat

format

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

Quality Level

300

Quality Level

200

Quality Level

300

Quality Level

300

General description

Praziquantel is at present the only drug used for the treatment of human schistosomiasis. It has a pyrazino isoquinoline ring system and is found to be very successful in animals for its anticestode and antitrematode properties. It has been identified that the voltage-gated schistosome calcium ion (Ca2+) channels serve as a target for praziquantel. Even though the commercial preparation of praziquantel comprises of equal amounts of both its ‘dextro′ and ‘laevo′ isomers, only the ‘laevo′ form exhibits schistosomicidal activity.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Praziquantel may be used as a pharmaceutical reference standard in the determination of the analyte in pharmaceutical preparations by electrochemical, spectrophotometric, and chromatographic techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA1898 in the slot below. This is an example certificate only and may not be the lot that you receive.

Hazard Statements

Precautionary Statements

Hazard Classifications

Aquatic Chronic 3

Storage Class Code

11 - Combustible Solids

WGK

WGK 1


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Schistosomiasis control: praziquantel forever?
Cioli D, et al.
Molecular and Biochemical Parasitology, 195(1), 23-29 (2014)
A rapid stability indicating LC-method for determination of praziquantel in presence of its pharmacopoeial impurities
Hashem H, et al.
Arabian Journal of Chemistry, 10(2), S35-S41 (2017)
Colorimetric procedure for the microdetermination of the antibilharzial drug praziquantel and its applications to pharmaceutical formulations
Amin AS and Ahmed IS
Microchimica Acta, 137(1-2), 35-40 (2001)
Simultaneous determination of albendazole and praziquantel by second derivative spectrophotometry and multivariated calibration methods in veterinary pharmaceutical formulation
Soto C, et al.
Analytical Sciences, 26(8), 891-896 (2010)
Praziquantel
Cioli D and Pica-Mattoccia L
Parasitology Research, 90(1), S3-S9 (2003)

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