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PHR1425

Supelco

Benzethonium Chloride

Pharmaceutical Secondary Standard; Certified Reference Material

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Synonym(s):
Benzethonium chloride, (Diisobutylphenoxyethoxyethyl)dimethylbenzylammonium chloride, Phemerol chloride
Empirical Formula (Hill Notation):
C27H42ClNO2
CAS Number:
Molecular Weight:
448.08
Beilstein:
3898548
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

Agency

traceable to Ph. Eur. B0550000
traceable to USP 1051500

API family

benzethonium chloride

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

162-164 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

[Cl-].CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1

InChI

1S/C27H42NO2.ClH/c1-26(2,3)22-27(4,5)24-13-15-25(16-14-24)30-20-19-29-18-17-28(6,7)21-23-11-9-8-10-12-23;/h8-16H,17-22H2,1-7H3;1H/q+1;/p-1

InChI key

UREZNYTWGJKWBI-UHFFFAOYSA-M

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This Item
B8879PHR1226PHR1681
Benzethonium Chloride Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1425

Benzethonium Chloride

Benzethonium chloride ≥97% (titration), ≥98% (HPLC)

Sigma-Aldrich

B8879

Benzethonium chloride

Cetylpyridinum chloride Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1226

Cetylpyridinum chloride

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

-

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

-

application(s)

pharmaceutical (small molecule)

application(s)

microbiology

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

format

neat

format

-

format

neat

format

single component solution

storage temp.

2-30°C

storage temp.

-

storage temp.

2-8°C

storage temp.

2-30°C

Quality Level

300

Quality Level

-

Quality Level

300

Quality Level

300

General description

Benzethonium Chloride, a quaternary ammonium drug, exhibits anti-infective, antiseptic and anticancer activities. It is commonly used in various commercial applications including eye and nasal drops, soaps, mouthwash, and cosmetics.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Benzethonium Chloride may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA2733 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Corr. 1B

Storage Class Code

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 2


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Customers Also Viewed

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Studies on the interactions of some small biomolecules with antibacterial drug benzethonium chloride and its active pharmaceutical ingredient ionic liquid (API-IL) benzethonium L-proline at varying temperatures
Yan Z, et al.
Journal of Molecular Liquids, 255, 530-540 (2018)
Effects of consumer antimicrobials benzalkonium chloride, benzethonium chloride, and chloroxylenol on colonic inflammation and colitis-associated colon tumorigenesis in mice
Sanidad KZ, et al.
Toxicological Sciences, 163(2), 490-499 (2018)
Determination of benzalkonium chloride preservative in pharmaceutical formulation of eye and ear drops using new potentiometric sensors
Gaber M, et al.
Materials Science and Engineering, C, 32(8), 2299-2305 (2012)
Development and validation of a capillary zone electrophoresis method for the determination of benzalkonium chlorides in ophthalmic solutions
Hou YH, et al.
Journal of Chromatography A, 976(1-2), 207-213 (2002)
T Marques et al.
Clinica chimica acta; international journal of clinical chemistry, 444, 170-175 (2015-02-24)
Mesangial cells subject to high extracellular glucose concentrations, as occur in hyperglycaemic states, are unable to down regulate glucose influx, resulting in intracellular activation of deleterious biochemical pathways. A high expression of GLUT1 participates in the development of diabetic glomerulopathy.

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