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SMB00940

Sigma-Aldrich

3-Hydroxyhippuric acid

≥95% (NMR)

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Synonym(s):
3-Hydroxyhippuric acid, (3-Hydroxybenzamido)acetic acid, (3-Hydroxybenzoylamino)acetic acid, 3-Hydroxybenzoylglycine, N-(3-Hydroxybenzoyl)glycine
Empirical Formula (Hill Notation):
C9H9NO4
CAS Number:
Molecular Weight:
195.17

Quality Level

assay

≥95% (NMR)

form

solid

color

white to pale yellow

storage temp.

2-8°C

SMILES string

OC(=O)CNC(=O)C1=CC=CC(O)=C1

InChI

1S/C9H9NO4/c11-7-3-1-2-6(4-7)9(14)10-5-8(12)13/h1-4,11H,5H2,(H,10,14)(H,12,13)

InChI key

XDOFWFNMYJRHEW-UHFFFAOYSA-N

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343668W288918W317004
Sigma-Aldrich

SMB00940

3-Hydroxyhippuric acid

2-Hydroxy-3-isopropylbenzoic acid 98%

343668

2-Hydroxy-3-isopropylbenzoic acid

3-Phenylpropionic acid 99%, FG

W288918

3-Phenylpropionic acid

trans-3-Hexenoic acid ≥98%, FG

W317004

trans-3-Hexenoic acid

assay

≥95% (NMR)

assay

98%

assay

99%

assay

≥98%

storage temp.

2-8°C

storage temp.

-

storage temp.

-

storage temp.

-

color

white to pale yellow

color

-

color

-

color

-

Quality Level

100

Quality Level

-

Quality Level

400

Quality Level

400

General description

3-Hydroxyhippuric acid is an acyl glycine. Acyl glycines are normally minor metabolites of fatty acids. However, the excretion of certain acyl glycines is increased in several inborn errors of metabolism. In certain cases the measurement of these metabolites in body fluids can be used to diagnose disorders associated with mitochondrial fatty acid beta-oxidation. Acyl glycines are produced through the action of glycine N-acyltransferase (EC 2.3.1.13) which is an enzyme that catalyzes the chemical reaction: acyl-CoA + glycine < -- > CoA + N-acylglycine. 3-Hydroxyhippuric acid is an organic acid found in normal human urine. 3-Hydroxyhippuric acid is a metabolite of rutin detected in urine after consumption of tomato juice (a source of rutin). 3-Hydroxyhippuric acid has its origin in dietary procyanidins (a major source of polyphenols consisting of elementary flavan-3-ol (epi)catechin units). 3-Hydroxyhippuric acid is a microbial aromatic acid metabolite derived from dietary polyphenols and flavonoids, found in normal human urine. It is a marker of gut Clostridium species. Higher levels are associated with higher levels of Clostridia.

Application

3-Hydroxyhippuric acid is a versatile molecule and it finds application in microbiome, biochemical and metabolomics research.

Features and Benefits

  • Can be used in Metabolomics and Biochemical research
  • High-quality compound suitable for multiple research applications

Other Notes

For additional information on our range of Biochemicals, please complete this form.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Marie-Paule Gonthier et al.
Free radical biology & medicine, 35(8), 837-844 (2003-10-15)
Procyanidins are major dietary polyphenols made of elementary flavan-3-ol (epi)catechin units. They have antioxidant properties and may contribute to health benefits in humans, but little is known about their metabolic fate. We compared here the metabolism of procyanidin dimer B3
Xiyue Xiong et al.
BioMed research international, 2016, 9485412-9485412 (2016-04-29)
Autism spectrum disorders (ASDs) are a group of mental illnesses highly correlated with gut microbiota. Recent studies have shown that some abnormal aromatic metabolites in autism patients are presumably derived from overgrown Clostridium species in gut, which may be used
Marie-Paule Gonthier et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 789(2), 247-255 (2003-05-14)
An HPLC-ESI-MS-MS method was developed to quantify in human urine fourteen aromatic acids known as metabolites of dietary polyphenols. These metabolites were determined simultaneously in a single 20-min chromatographic analysis with multiple reaction monitoring detection. The inter- and intra-day precisions
Indu B Jaganath et al.
Free radical research, 40(10), 1035-1046 (2006-10-04)
Tomato juice containing rutin (quercetin-3-rutinoside) was ingested by healthy volunteers and ileostomists. Blood and urine collected over 24 h were analysed by HPLC with photodiode array (PDA) and tandem mass spectrometric detection. Low concentrations of isorhamnetin-3-glucuronide (Cmax = 4.3 +/-
Andreas R Rechner et al.
Free radical research, 36(11), 1229-1241 (2003-02-21)
Berry extracts rich in anthocyanins have been linked to protective effects including the modulation of age-related neurological dysfunction and the improvement of the resistance of red blood cells against oxidative stress in vitro. In this study the bioavailability, metabolism and

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