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T8656

Sigma-Aldrich

Thiourea

ACS reagent, ≥99.0%

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Synonym(s):
Sulfourea, Thiocarbamide
Linear Formula:
NH2CSNH2
CAS Number:
62-56-6
Molecular Weight:
76.12
Beilstein/REAXYS Number:
605327
EC Number:
200-543-5
MDL number:
MFCD00008067
UNSPSC Code:
12352100
PubChem Substance ID:
24900549
NACRES:
NA.21

grade

ACS reagent

Quality Level

200

assay

≥99.0%

ign. residue

≤0.1% (as SO4)

loss

≤0.5% loss on drying, 105°C, 2h

mp

170-176 °C (lit.)
174-177 °C

solubility

H2O: passes test

SMILES string

NC(N)=S

InChI

1S/CH4N2S/c2-1(3)4/h(H4,2,3,4)

InChI key

UMGDCJDMYOKAJW-UHFFFAOYSA-N

Gene Information

mouse ... Ephx2(13850)

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General description

Thiourea is an analogue of urea containing sulphur.

Application

Thiourea has been used:
  • as a component of lysis buffer for liver tissue homogenization
  • in 2-D sample buffer for two-dimensional in-gel protein tyrosine phosphatases (PTP) assay
  • in rehydration buffer for protein extraction

Chaotropic agent; strong denaturant. Increases solubility and recovery of proteins

Biochem/physiol Actions

Thiourea is a free radical scavenger of the peroxide radical. It was shown to inhibit lipid peroxidation and ultraviolet (UV)-induced crosslinking of collagen. Bud dormancy in plants can be inhibited by thiourea which is used as a growth stimulator. It is also known to be used in the treatment of hyperthyroidism.

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 2 - Carc. 2 - Repr. 2

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Certificates of Analysis (COA)

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Effect of copper nanoparticles exposure in the physiology of the common carp (Cyprinus carpio): Biochemical, histological and proteomic approaches
Gupta YR, et al.
Aquaculture and Fisheries, 1(2), 15-23 (2016)
Investigation of protein-tyrosine phosphatases by in-gel assays.
Markova B, et al.
Methods, 35(1), 22-27 (2005)
Mechanism of the reduction of methylene blue by thiourea in aqueous acidic medium
Osunlaja AA
International Journal of ChemTech Research, 4(2), 609-617 (2012)
Yoshiji Takemoto
Chemical & pharmaceutical bulletin, 58(5), 593-601 (2010-05-13)
We have developed several multifunctional thiourea catalysts bearing a tertiary amine or an 1,2-amino alcohol in expectation of their synchronous activation of a nucleophile and an electrophile through both acid-base and hydrogen-bonding interactions. From these studies, it was revealed that
Elaine M Boyle et al.
The Journal of organic chemistry, 78(17), 8312-8319 (2013-08-01)
Thiourea-functionalized Tröger's base receptors 1 and 2 have been synthesized and evaluated as novel for the recognition of anions. Receptor 2 gave rise to significant changes in the absorption spectrum upon titration with AcO(-) and H2PO4(-) and acted as a
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