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Y0001183

Trolamine impurity B

European Pharmacopoeia (EP) Reference Standard

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Synonym(s):
Diethanolamine, 2,2′-Iminodiethanol, Bis(2-hydroxyethyl)amine
Linear Formula:
HN(CH2CH2OH)2
CAS Number:
Molecular Weight:
105.14
Beilstein:
605315
MDL number:
PubChem Substance ID:
NACRES:
NA.24

grade

pharmaceutical primary standard

vapor density

3.6 (vs air)

vapor pressure

<0.98 atm ( 100 °C)

API family

trolamine

autoignition temp.

689 °F

expl. lim.

10.6 %

manufacturer/tradename

EDQM

refractive index

n20/D 1.477 (lit.)

bp

217 °C/150 mmHg (lit.)

mp

28 °C (lit.)

density

1.097 g/mL at 25 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

OCCNCCO

InChI

1S/C4H11NO2/c6-3-1-5-2-4-7/h5-7H,1-4H2

InChI key

ZBCBWPMODOFKDW-UHFFFAOYSA-N

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This Item
1192808Y0001184T2545000
Trolamine impurity B European Pharmacopoeia (EP) Reference Standard

Y0001183

Trolamine impurity B

Diethanolamine United States Pharmacopeia (USP) Reference Standard

USP

1192808

Diethanolamine

Trolamine impurity A European Pharmacopoeia (EP) Reference Standard

Y0001184

Trolamine impurity A

Trolamine European Pharmacopoeia (EP) Reference Standard

T2545000

Trolamine

manufacturer/tradename

EDQM

manufacturer/tradename

USP

manufacturer/tradename

EDQM

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

format

neat

format

neat

format

neat

format

neat

vapor density

3.6 (vs air)

vapor density

3.6 (vs air)

vapor density

2.1 (vs air)

vapor density

5.14 (vs air)

vapor pressure

<0.98 atm ( 100 °C)

vapor pressure

<0.98 atm ( 100 °C)

vapor pressure

0.2 mmHg ( 20 °C)

vapor pressure

0.01 mmHg ( 20 °C)

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Trolamine impurity B EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Repr. 2 - Skin Irrit. 2 - STOT RE 2 Oral

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

280.4 °F - closed cup

Flash Point(C)

138 °C - closed cup


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Hon-Wing Leung et al.
Regulatory toxicology and pharmacology : RTP, 43(3), 260-271 (2005-09-29)
Diethanolamine (DEA) is a chemical used widely in a number of industries and is present in many consumer products. Studies by the National Toxicology Program (NTP) have indicated that lifetime dermal exposure to DEA increased the incidence and multiplicity of
Honghui Yu et al.
Journal of immunology (Baltimore, Md. : 1950), 193(6), 2902-2910 (2014-08-15)
Anti-D can prevent immunization to the RhD Ag on RBCs, a phenomenon commonly termed Ab-mediated immune suppression (AMIS). The most accepted theory to explain this effect has been the rapid clearance of RBCs. In mouse models using SRBC, these xenogeneic
Hae-Rim Kim et al.
PloS one, 10(4), e0124909-e0124909 (2015-04-22)
Vascular endothelial growth factor (VEGF) has angiogenic, inflammatory, and bone-destructive roles in rheumatoid arthritis (RA). We aimed to determine the unique role of VEGF in osteoclastogenesis in RA. VEGF-induced receptor activator of nuclear factor ҡB ligand (RANKL) expression was determined
Choline deficiency associated with diethanolamine carcinogenicity.
Paul M Newberne
Toxicological sciences : an official journal of the Society of Toxicology, 67(1), 1-3 (2002-04-19)
M-L Metzger et al.
Clinical and experimental immunology, 179(2), 256-264 (2014-09-25)
Common variable immunodeficiency (CVID) encompasses a heterogeneous group of antibody deficiencies characterized by susceptibility to recurrent infections and sequelae, including bronchiectasis. We investigated the relevance of the lectin complement pathway in CVID patients by analysing ficolin-2 and ficolin-3 serum levels

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