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87368

Sigma-Aldrich

Tetrahydrofuran

contains 250 ppm BHT as inhibitor, puriss. p.a., ACS reagent, reag. Ph. Eur., ≥99.9%

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Synonym(s):
Butylene oxide, Oxolane, Tetramethylene oxide
Empirical Formula (Hill Notation):
C4H8O
CAS Number:
Molecular Weight:
72.11
Beilstein/REAXYS Number:
102391
EC Number:
MDL number:
PubChem Substance ID:

grade

ACS reagent
puriss. p.a.

Quality Level

agency

reag. Ph. Eur.

vapor density

2.5 (vs air)

vapor pressure

114 mmHg ( 15 °C)
143 mmHg ( 20 °C)

assay

≥99.9%

form

liquid

autoignition temp.

610 °F

contains

250 ppm BHT as inhibitor
~0.025% 2,6-di-tert-butyl-4-methylphenol as stabilizer

expl. lim.

1.8-11.8 %

technique(s)

solid phase extraction (SPE): suitable

impurities

≤0.001% free acid (as CH3COOH)
≤0.005% peroxides (as H2O2)
≤0.05% water

evapn. residue

≤0.001%

refractive index

n20/D 1.407 (lit.)
n20/D 1.407

pH

~7

bp

65-67 °C (lit.)

mp

−108 °C (lit.)

density

0.887 g/mL at 20 °C
0.889 g/mL at 25 °C (lit.)

cation traces

Al: ≤0.5 mg/kg
B: ≤0.02 mg/kg
Ba: ≤0.1 mg/kg
Bi: ≤0.1 mg/kg
Ca: ≤0.5 mg/kg
Cd: ≤0.05 mg/kg
Co: ≤0.02 mg/kg
Cr: ≤0.02 mg/kg
Cu: ≤0.02 mg/kg
Fe: ≤0.1 mg/kg
K: ≤0.5 mg/kg
Li: ≤0.1 mg/kg
Mg: ≤0.1 mg/kg
Mn: ≤0.02 mg/kg
Mo: ≤0.1 mg/kg
Na: ≤0.5 mg/kg
Ni: ≤0.02 mg/kg
Pb: ≤0.1 mg/kg
Sn: ≤0.1 mg/kg
Sr: ≤0.1 mg/kg
Zn: ≤0.1 mg/kg

SMILES string

C1CCOC1

InChI

1S/C4H8O/c1-2-4-5-3-1/h1-4H2

InChI key

WYURNTSHIVDZCO-UHFFFAOYSA-N

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1 of 4

This Item
67676418656234865
vibrant-m

87368

Tetrahydrofuran

Essential Grade
vibrant-m

676764

Tetrahydrofuran

Essential Grade
vibrant-m

186562

Tetrahydrofuran

-
vibrant-m

34865

Tetrahydrofuran

-
assay

≥99.9%

assay

≥99.0%

assay

≥99.9%

assay

≥99.9%

grade

ACS reagent, puriss. p.a.

grade

ACS reagent

grade

anhydrous

grade

-

form

liquid

form

liquid

form

liquid

form

liquid

technique(s)

solid phase extraction (SPE): suitable

technique(s)

HPLC: suitable

technique(s)

-

technique(s)

HPLC: suitable

vapor density

2.5 (vs air)

vapor density

2.5 (vs air)

vapor density

2.5 (vs air)

vapor density

2.5 (vs air)

General description

The product is tetrahydrofuran (THF) and it contains 250ppm BHT (Butylated hydroxytoluene) as an inhibitor. THF is widely employed as a solvent. It constitutes the key fragment of various natural products (polyether antibiotics). THF forms double hydrate with hydrogen sulfide. Crystal structure of this double hydrate has been investigated by three-dimensional single-crystal studies. Butane-1,4-diol is formed as an intermediate during the synthesis of THF. Hot THF is useful for the dissolution of polyvinylidene chloride (PVDV).

Application

Tetrahydrofuran has been used as a solvent for the preparation of sol-gel solution for coating solid phase microextraction (SPME) fibers in a study.

It may be used for the dissolution of poly-ε-caprolactone (PCL) and 1,3-diaminopentane, during the preparation of poly-ε-caprolactone (PCL)-hydroxyapatite (HA) scaffolds and acrylate-terminated poly(5-amino-1-pentanol-co-1,4-butanediol diacrylate) (C32)- 1,3-diaminopentane (117) polymer, respectively.

Analysis Note

miscible with water and ethanol (96%) pass

Other Notes

The article number 87368-6X1L-M will be discontinued. Please order the single bottle 87368-1L-M which is physically identical with the same exact specifications.
Sales restrictions may apply

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Flam. Liq. 2

supp_hazards

Storage Class

3 - Flammable liquids

wgk_germany

WGK 1

flash_point_f

-6.2 °F - closed cup

flash_point_c

-21.2 °C - closed cup


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Polyhedral clathrate hydrates. X. Structure of the double hydrate of tetrahydrofuran and hydrogen sulfide.
Mak TCW, et al.
J. Chem. Phys. , 42(8), 2732-2737 (1965)
Synthetic routes to tetrahydrofuran, tetrahydropyran, and spiroketal units of polyether antibiotics and a survey of spiroketals of other natural products.
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Tetrahedron, 43(15), 3309-3362 (1987)

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