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123M-2

Sigma-Aldrich

CD23 (MRQ-57) Mouse Monoclonal Antibody

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NACRES:
NA.41

biological source

mouse

Quality Level

100
500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

MRQ-57, monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (123M-24)
vial of 0.5 mL concentrate (123M-25)
bottle of 1.0 mL predilute (123M-27)
vial of 1.0 mL concentrate (123M-26)
bottle of 7.0 mL predilute (123M-28)

manufacturer/tradename

Cell Marque

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

isotype

IgG2a

control

chronic lymphocytic leukemia, lymph node, small lymphocytic lymphoma, tonsil

shipped in

wet ice

storage temp.

2-8°C

visualization

membranous

Gene Information

human ... FCER2(2208)

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This Item
123R-2123R-1121M-1
biological source

mouse

biological source

rabbit

biological source

rabbit

biological source

mouse

antibody form

culture supernatant

antibody form

culture supernatant

antibody form

culture supernatant

antibody form

culture supernatant

clone

MRQ-57, monoclonal

clone

EP75, monoclonal

clone

SP23, monoclonal

clone

2G9, monoclonal

species reactivity

human

species reactivity

human

species reactivity

human

species reactivity

human

Gene Information

human ... FCER2(2208)

Gene Information

human ... FCER2(2208)

Gene Information

human ... FCER2(2208)

Gene Information

human ... CR2(1380)

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General description

CD23 antigen is a 45-60 kDa membrane glycoprotein identified as a low affinity receptor for IgE production as well as a receptor for lymphocyte growth factor. CD23 is found in some mature B-cell lymphomas and in Reed-Sternberg cells in Hodgkin disease. Follicular dendritic cells and some activated B-cells within germinal centers express CD23 in high density and mantle zone B-cells are stained weakly.The majority of chronic lymphocytic leukemias/small lymphocytic lymphomas are CD23 positive, whereas mantle cell lymphomas are generally negative, so this marker is useful when applied with other markers to separate the small cell lymphomas.Precursor B and T lymphomas, myeloid neoplasms, and mature T-cell lymphomas are CD23 negative and other small cell lymphomas are occasionally positive.CD23 is also positive on activated mature B-cells expressing IgM or IgD, monocytes/macrophages, follicular dendritic cells, T-cell subsets, eosinophils, Langerhans cells and B-cell Chronic lymphocytic leukemia/Small lymphocytic lymphoma (CLL/SLL).

Quality


IVD

IVD

IVD

RUO

Linkage

CD23 Positive Control Slides, Product No. 123S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


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D C Rowlands et al.
The Journal of pathology, 160(3), 239-243 (1990-03-01)
The leukocyte antigen CD23 is expressed during B-cell development, and functions as an IgE receptor and a lymphocyte growth factor. We studied the expression of CD23 in paraffin sections of lymphoid tissue using the monoclonal antibody BU38. Fifteen cases of
S Raghoebier et al.
Blood, 78(10), 2680-2685 (1991-11-15)
Large cell lymphomas (LCLs) are heterogeneous in morphology, clinical presentation, and behavior. We studied 52 de novo LCLs of B-cell type for rearrangements of the bcl-2 and c-myc oncogenes by Southern blot analysis and related these data to the primary
Francesco DiRaimondo et al.
Cancer, 94(6), 1721-1730 (2002-03-29)
CD23 antigen is a cell surface protein considered important in the differentiation of chronic lymphocytic leukemia (CLL) from other lymphoid leukemias. To better clarify CD23 role as a diagnostic tool, the authors retrospectively evaluated clinical and laboratory features of 372

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