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30070

Sigma-Aldrich

Cysteamine

≥98.0% (RT)

Synonym(s):

β-Mercaptoethylamine, 2-Aminoethanethiol, 2-Mercaptoethylamine, Decarboxycysteine, MEA, Thioethanolamine

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About This Item

Linear Formula:
NH2CH2CH2SH
CAS Number:
60-23-1
Molecular Weight:
77.15
Beilstein/REAXYS Number:
635649
EC Number:
200-463-0
MDL number:
MFCD00008196
UNSPSC Code:
12352116
PubChem Substance ID:
57648397
NACRES:
NA.25

Quality Level

200

assay

≥98.0% (RT)

storage temp.

2-8°C

SMILES string

NCCS

InChI

1S/C2H7NS/c3-1-2-4/h4H,1-3H2

InChI key

UFULAYFCSOUIOV-UHFFFAOYSA-N

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Application

Cysteamine is suitable for use:
  • in the preparation of cysteamine modified gold nanoparticles (AuNP)
  • in the fabrication of SU-8 microrods, where in, the amine group of cysteamine reacts with the unreacted epoxide rings present on the surface of the particles, thereby opening it and forming a covalent bond
  • to enhance in vitro development of porcine oocytes matured and fertilized in vitro
  • in a study to demonstrate the depletion effect of cysteamine on cystinotic leucocyte granular fractions of cystine by disulphide interchange
  • as a radioprotector
  • to administer subcutaneously in rats to study its blocking effect on somatostatin secretion without modifying the pancreatic insulin or glucagon content
  • as a scavenger in electrophoretic gels (acetic acid/urea gels)

Biochem/physiol Actions

Cysteamine (β-mercaptoethylamine) depletes cystine from patient′s cells and there by regulates renal glomerular function and increases growth in them. Therefore, cysteamine is considered to be a potential therapeutic for nephropathic cystinosis.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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W A Gahl et al.
The Biochemical journal, 228(3), 545-550 (1985-06-15)
Cystinotic lysosome-rich leucocyte granular fractions, loaded with [35S]cystine, were exposed to different cystine-depleting agents. During a 30 min incubation at 37 degrees C, untreated cystinotic granular fractions lost negligible [35S]cystine when corrected for lysosome rupture. Granular fractions exposed to 0.1
Successful treatment of severe paracetamol overdosage with cysteamine.
L F Prescott et al.
Lancet (London, England), 1(7858), 588-592 (1974-04-06)
M J Barratt et al.
Proceedings of the National Academy of Sciences of the United States of America, 91(11), 4781-4785 (1994-05-24)
Diverse agents, including growth factors and phorbol esters, induce rapid transcriptional activation of a subset of immediate-early (IE) genes that include the protooncogenes c-fos and c-jun. Among the earliest nuclear signaling events concomitant with IE gene activation is the phosphorylation
Automatic microcircuit formation based on gold-coated SU-8 microrods via dielectrophoresis.
Yu-Kun R, et al.
Chinese Physics B, 22 (2013)
J Carmichael et al.
Cancer research, 47(4), 943-946 (1987-02-15)
Radiation survival curves were generated for V79 Chinese hamster and two human lung cancer cell lines (NCI-H460 and NCI-H249) with doubling times of 10, 20, and 85 h, respectively, using a standard clonogenic assay, a dye exclusion assay, and a
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