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426R-1

Sigma-Aldrich

STAT6 (EP325) Rabbit Monoclonal Primary Antibody

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Synonym(s):
Signal Transducer and Activator of Transcription

biological source

rabbit

Quality Level

100
500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

EP325, monoclonal

description

For In Vitro Diagnostic Use in Select Regions

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (426R-14)
vial of 0.1 mL concentrate Research Use Only (426R-14-RUO)
vial of 0.5 mL concentrate (426R-15)
vial of 1.0 mL concentrate (426R-16)
vial of 1.0 mL concentrate Research Use Only (426R-16-RUO)
vial of 1.0 mL pre-dilute Research Use Only (426R-17-RUO)
vial of 1.0 mL pre-dilute ready-to-use (426R-17)
vial of 7.0 mL pre-dilute ready-to-use (426R-18)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (426R-18-RUO)

manufacturer/tradename

Cell Marque

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 (concentrated)

isotype

IgG

control

solitary fibrous tumor

shipped in

wet ice

storage temp.

2-8°C

visualization

nuclear

Gene Information

human ... STAT6(6778)

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This Item
05-106405-886R07-1352
conjugate

unconjugated

conjugate

-

conjugate

-

conjugate

-

antibody form

culture supernatant

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

antibody form

affinity isolated antibody

species reactivity

human

species reactivity

rat, mouse, human

species reactivity

mouse, human, rat

species reactivity

human

clone

EP325, monoclonal

clone

5C9.2, monoclonal

clone

94-10C-9-10C-2, monoclonal

clone

polyclonal

isotype

IgG

isotype

IgG1κ

isotype

IgG

isotype

-

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General description

STAT6, a member of the signal transducers and activators of transcription (STAT) family, has been found to form recurrent fusions with NAB2 on chromosome 12q13 in the majority of solitary fibrous tumors. Inactivated STAT6 can be found in the form of a dimer located in the cytoplasm. STAT6 and NAB2 fusion enables cytosolic STAT6 to migrate to the nucleus and thus allowing for detection in immunohistochemical assays. NAB2-STAT6 fusion transcriptions have been reported in the majority of solitary fibrous tumors but not in meningiomas, hemangioblastomas, schwannomas, and hemangiomas. This makes STAT6 a useful marker in distinguishing solitary fibrous tumors from other morphologically similar tumors.

Quality


IVD

IVD

IVD

RUO

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

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Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

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Alison L Cheah et al.
Pathology, 46(5), 389-395 (2014-07-01)
Recurrent NAB2-STAT6 gene fusions have recently been identified in solitary fibrous tumour by next generation sequencing. Our aim was to examine the sensitivity and specificity of STAT6 immunohistochemistry for solitary fibrous tumour versus other morphologically similar soft tissue tumours. STAT6
Christian Koelsche et al.
Histopathology, 65(5), 613-622 (2014-04-08)
Nuclear relocation of STAT6 has been shown in tumours with NAB2-STAT6 fusion, and has been proposed as an ancillary marker for the diagnosis of solitary fibrous tumours (SFTs). The aim of this study was to verify the utility of STAT6
Leonille Schweizer et al.
Acta neuropathologica, 125(5), 651-658 (2013-04-12)
Non-central nervous system hemangiopericytoma (HPC) and solitary fibrous tumor (SFT) are considered by pathologists as two variants of a single tumor entity now subsumed under the entity SFT. Recent detection of frequent NAB2-STAT6 fusions in both, HPC and SFT, provided

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