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45703

Sigma-Aldrich

Erythromycin standard solution

1 mg/mL in H2O

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Synonym(s):
Erythromycin from Streptomyces erythreus
Empirical Formula (Hill Notation):
C37H67NO13
CAS Number:
Molecular Weight:
733.93
Beilstein/REAXYS Number:
8183758
MDL number:
PubChem Substance ID:
NACRES:
NA.85

biological source

Streptomyces erythreus (strains)

agency

EPA 1694

form

liquid

concentration

1 mg/mL in H2O

color

colorless

antibiotic activity spectrum

Gram-positive bacteria

application(s)

environmental

mode of action

protein synthesis | interferes

storage temp.

2-8°C

SMILES string

CC[C@H]1OC(=O)[C@H](C)C(O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)C(C)C(OC3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)C(O)[C@]1(C)O

InChI

1S/C37H67NO13/c1-14-25-37(10,45)30(41)20(4)27(39)18(2)16-35(8,44)32(51-34-28(40)24(38(11)12)15-19(3)47-34)21(5)29(22(6)33(43)49-25)50-26-17-36(9,46-13)31(42)23(7)48-26/h18-26,28-32,34,40-42,44-45H,14-17H2,1-13H3/t18-,19-,20+,21+,22-,23+,24+,25-,26+,28-,29+,30-,31+,32-,34+,35-,36-,37-/m1/s1

InChI key

ULGZDMOVFRHVEP-RWJQBGPGSA-N

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This Item
45674E5389BP781
Erythromycin standard solution 1 mg/mL in H2O

45703

Erythromycin standard solution

Erythromycin tested according to Ph. Eur.

45674

Erythromycin

Erythromycin BioReagent, suitable for cell culture

E5389

Erythromycin

Erythromycin British Pharmacopoeia (BP) Reference Standard

BP781

Erythromycin

antibiotic activity spectrum

Gram-positive bacteria

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

antibiotic activity spectrum

-

application(s)

environmental

application(s)

environmental

application(s)

-

application(s)

pharmaceutical

form

liquid

form

solid

form

powder

form

-

biological source

Streptomyces erythreus (strains)

biological source

-

biological source

-

biological source

-

storage temp.

2-8°C

storage temp.

-

storage temp.

-

storage temp.

−20°C

General description

Chemical structure: macrolide

Application

Erythromycin is an antibiotic produced by growth of certain strains of Streptomyces erythreus. This product is composed largely of erythromycin A with small amounts of erythromycins B and C and is recommended for concentration at 100 mg/L. Concentrations between 50 and 200 mg/L have also proven effective in controlling bacterial growth. Erythromycin has been used as a motilin receptor agonist, to block respiratory glycoconjugate secretion in human airways in vitro, and for selecting plasmid-cured and recombinant lactococcus lactis MG1363 strains. .

Biochem/physiol Actions

Mode of Action: Erythromycin acts by inhibiting elongation at the transpeptidation step, specifically aminoacyl translocation from the A-site to P-site by binding to the 50s subunit of the bacterial 70s rRNA complex.

Antimicrobial Spectrum: This product acts against both gram-negative and gram-positive bacteria.

Packaging

10 ml

Caution

This Erythromycin solution is concentrated at 1 mg/mL in H2O and is stable in solution at 37°C for 3 days. Stock solutions should be stored at 2-8°C.

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Store under inert gas.

Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves


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J I Alós et al.
The Journal of antimicrobial chemotherapy, 51(2), 333-337 (2003-02-04)
In 1998 we conducted a multicentre study in Spain on the susceptibility of Streptococcus pyogenes isolates to different 14-, 15- and 16-membered macrolides and clindamycin, in which the number of strains examined was proportional to the number of inhabitants in
Pier Carlo Braga et al.
The Journal of antimicrobial chemotherapy, 50(4), 457-460 (2002-10-03)
The aim of this study was to use atomic force microscopy (AFM), an innovative type of microscopy, to investigate the different behaviours of erythromycin A (a 14-membered ring) and rokitamycin (a 16-membered ring) in disrupting the morphology of Streptococcus pyogenes
Agot Aakra et al.
Antimicrobial agents and chemotherapy, 49(6), 2246-2259 (2005-05-27)
A transcriptional profile of Enterococcus faecalis V583 (V583) treated with erythromycin is presented. This is the first study describing a complete transcriptional profile of Enterococcus. E. faecalis is a common and nonvirulent bacterium in many natural environments, but also an
Christoph Czarnetzki et al.
JAMA surgery, 150(8), 730-737 (2015-06-18)
Patients undergoing emergency procedures under general anesthesia have impaired gastric emptying and are at high risk for aspiration of gastric contents. Erythromycin has strong gastric prokinetic properties. To evaluate the efficacy of erythromycin lactobionate in gastric emptying in patients undergoing
David J Serisier et al.
JAMA, 309(12), 1260-1267 (2013-03-28)
Macrolide antibiotics such as erythromycin may improve clinical outcomes in non-cystic fibrosis (CF) bronchiectasis, although associated risks of macrolide resistance are poorly defined. To evaluate the clinical efficacy and antimicrobial resistance cost of low-dose erythromycin given for 12 months to

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