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502-05A

Sigma-Aldrich

Human Bronchial Epithelial Cells: HBEpC, adult

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Synonym(s):
HBEpC, HBEpC cells
NACRES:
NA.81

biological source

human bronchi (normal surface epithelium)

Quality Level

packaging

pkg of 500,000 cells

manufacturer/tradename

Cell Applications, Inc

growth mode

Adherent

karyotype

2n = 46

morphology

epithelial

technique(s)

cell culture | mammalian: suitable

relevant disease(s)

asthma; autoimmune diseases; cardiovascular diseases

shipped in

dry ice

storage temp.

−196°C

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This Item
C-12642504-05A104-05A
karyotype

2n = 46

karyotype

-

karyotype

2n = 46

karyotype

2n = 46

Quality Level

100

Quality Level

-

Quality Level

100

Quality Level

100

morphology

epithelial

morphology

(epithelial)

morphology

epithelial

morphology

Epidermal

growth mode

Adherent

growth mode

-

growth mode

Adherent

growth mode

Adherent

relevant disease(s)

asthma; autoimmune diseases; cardiovascular diseases

relevant disease(s)

asthma

relevant disease(s)

cardiovascular diseases

relevant disease(s)

metabolic disorders

General description

Lot specific orders are not able to be placed through the web. Contact your local sales rep for more details.

HBEpC provide an excellent model system to study all aspects of epithelial function and disease, particularly those related to airway viral infections, as well as tissue repair mechanisms, signaling changes and potential treatments relevant to lung injuries, mechanical and oxidative stress, inflammation, pulmonary diseases and smoking.

When grown on inserts and provided with the liquid/air interface, HBEpC can differentiate into a pseudostriated epithelium and serve as a more physiological 3D tissue model for in vitro studies.

Cell Line Origin

Bronchi

application

epithelial function, tissue repair, cell signaling, lung injury treatment, mechanical and oxidative stress tests, cell differentiation, 3D tissue model, cytokine and growth factor production, apoptosis, cell adhesion molecules, cell permeability, pro-inflammatory signaling, viral fusion mechanisms, gene expression, library screening, mucin secretion

Components

Cell Basal Medium containing 10% FBS & 10% DMSO

Preparation Note

  • 1st passage, >500,000 cells in Cell Basal Medium containing 10% FBS & 10% DMSO
  • Can be cultured at least 16 doublings

Subculture Routine

Please refer to the HBEpC Culture Protocol.

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Anjana A Kulkarni et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 15(7), 2417-2425 (2009-03-26)
There is a lack of prognostic and predictive biomarkers in epithelial ovarian carcinoma, and the targeting of oncogenic signaling pathways has had limited impact on patient survival in this highly heterogeneous disease. The origin licensing machinery, which renders chromosomes competent
Khuloud Bajbouj et al.
International journal of molecular sciences, 22(11) (2021-07-03)
As a therapeutic approach, epigenetic modifiers have the potential to enhance the efficacy of chemotherapeutic agents. Protein arginine methyltransferase 5 (PRMT5), highly expressed in lung adenocarcinoma, was identified to be involved in tumorigenesis. In the current study, we examined the
Matthew Charman et al.
Frontiers in cellular and infection microbiology, 11, 689707-689707 (2021-10-09)
The induction of antiviral effector proteins as part of a homeostatically controlled innate immune response to infection plays a critical role in limiting the propagation and transmission of respiratory pathogens. However, the prolonged induction of this immune response can lead

Protocols

Technical information for working with human bronchial epithelial cell line including thawing, subculturing and cryopreservation.

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