Skip to Content
MilliporeSigma

70215

Sigma-Aldrich

2,3-Naphthalenedicarboxaldehyde

suitable for fluorescence

Synonym(s):

NDA

Sign Into View Organizational & Contract Pricing

Select a Size

250 MG
₩92,568

₩92,568


Please contact Customer Service for Availability

Request a Bulk Order

Select a Size

Change View
250 MG
₩92,568

About This Item

Linear Formula:
C10H6(CHO)2
CAS Number:
Molecular Weight:
184.19
Beilstein/REAXYS Number:
2207267
MDL number:
UNSPSC Code:
12352108
PubChem Substance ID:
NACRES:
NA.32

form:
crystals

₩92,568


Please contact Customer Service for Availability

Request a Bulk Order

form

crystals

Quality Level

impurities

≤2% mono- and dicarboxylic acid (1H-NMR)

mp

131-133 °C (lit.)
132-135 °C

fluorescence

λex 420 nm; λem ~480 nm in 0.1 M borate pH 9.3 (after derivatization with glycine [~90 μM glycine, ~20 μM N-])

suitability

suitable for fluorescence

storage temp.

2-8°C

SMILES string

[H]C(=O)c1cc2ccccc2cc1C([H])=O

InChI

1S/C12H8O2/c13-7-11-5-9-3-1-2-4-10(9)6-12(11)8-14/h1-8H

InChI key

ZIPLKLQPLOWLTM-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
466921759937687227
2-Oxindole 97%

O9808

2-Oxindole

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

form

crystals

form

solid

form

solid

form

solid

mp

123-128 °C (lit.)

mp

85-88 °C (lit.)

mp

106-110 °C

mp

72-78 °C

bp

227 °C/73 mmHg (lit.)

bp

-

bp

-

bp

-

Gene Information

human ... PGR(5241)

Gene Information

-

Gene Information

-

Gene Information

-

General description

2,3-Naphthalenedicarboxaldehyde, also known as NDA, is a novel fluorescent derivatization agent. The fluorescence max. excitation of NDA is in the range of 424 nm and max. emission is achieved at 484nm.[1]

2,3-Naphthalenedicarboxaldehyde is a fluorescent derivatization agent of primary amines, amino acids, and small peptides. The reaction between the amino compounds and NDA results in highly fluorescent and stable derivative compounds.

Application

2,3-Naphthalenedicarboxaldehyde is used as a fluorescent labelling agent for quantification of Histamine in human immunoglobulin preparations.[1] NAD is used as a derivatization agent for glutathione to quantify protein glutathionylation.[2] It is a suitable reagent used for the development of fluorescence-based microtiter plate assay for γ-glutamylcyclotransferase.[3]

Features and Benefits

NDA based fluorescent assays have the following benefits over O-Phthalaldehyde (OPA):

  • High Reaction rate.
  • High Fluorescence quantum yield.
  • No uncommon excitation wavelength.
  • No side reactions.

pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

T. Ueda et al.
Analytical Chemistry, 63, 2979-2979 (1991)
Richard C Kevin et al.
Forensic toxicology, 37(1), 17-26 (2019-02-02)
The use of novel synthetic cannabinoids as intoxicants continues in spite of associated health risks. These compounds are typically smoked or vaporized, but many synthetic cannabinoids contain thermally labile chemical moieties. This study investigated the thermal stability six carboxamide-type synthetic
Stéphanie Marchand et al.
Analytica chimica acta, 660(1-2), 158-163 (2010-01-28)
A simple and automated high performance liquid chromatography (HPLC) method for the separation and quantitative determination of gamma-glutamylcysteine and reduced glutathione (GSH) in wines is reported. This technique involves the use of a pre-column derivatization with 2,3-naphthalenedialdehyde (NDA), an isocratic
An improved mechanism-based cross-linker for multiplexed kinase detection and inhibition in a complex proteome.
Kai Liu et al.
Chembiochem : a European journal of chemical biology, 9(12), 1883-1888 (2008-07-16)
P. de Montigny et al.
Analytical Chemistry, 59, 1096-1096 (1987)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service