91C
Leukocyte Naphthol AS-D Chloroacetate (Specific Esterase) Kit
Synonym(s):
Leder Stain
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About This Item
NACRES:
NA.47
UNSPSC Code:
12352106
description
Kit formulated with all liquid reagents
shelf life
Expiry date on the label.
IVD
for in vitro diagnostic use
dilution
(for histology)
application(s)
hematology
histology
shipped in
wet ice
storage temp.
2-8°C
Quality Level
Related Categories
Application
Esterases are ubiquitous in nature and encompass a series of different enzymes acting upon select substrates. With the 91C kit, Naphthol AS-D Chloroacetate is enzymatically hydrolyzed by "specific esterase, " liberating a free naphthol compound. This then couples with a diazonium compound, forming highly colored deposits at sites of enzyme activity. This enzyme is usually considered specific for cells of granulocytic lineage. May be used to detect neutrophils in peripheral blood, bone marrow or tissue sections which have been paraffin embedded.
signalword
Danger
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1 - Met. Corr. 1 - Repr. 1B - Skin Corr. 1 - Skin Sens. 1 - STOT RE 2 Oral - STOT SE 3
target_organs
Kidney, Respiratory system
supp_hazards
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
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Ganesan Ramesh et al.
Kidney international, 65(2), 490-499 (2004-01-14)
Salicylate was recently shown to provide protection against cisplatin nephrotoxicity in rats. We have demonstrated that enhanced tumor necrosis factor-alpha (TNF-alpha) production mediates, in part, cisplatin nephrotoxicity. The purpose of this study was to determine if the protective effects of
Ralf A Linker et al.
Journal of immunology (Baltimore, Md. : 1950), 180(4), 2204-2213 (2008-02-06)
The neurotrophic cytokines ciliary neurotrophic factor and leukemia inhibitory factor (LIF) play a key role in neuronal and oligodendrocyte survival and as protective factors in neuroinflammation. To further elucidate the potential of endogenous LIF in modulating neuroinflammation, we studied myelin
Paramahamsa Maturu et al.
Translational oncology, 7(4), 484-492 (2014-06-28)
The role of inflammation in cancer has been reported in various adult malignant neoplasms. By contrast, its role in pediatric tumors has not been as well studied. In this study, we have identified and characterized the infiltration of various inflammatory
Tarek M El-Achkar et al.
American journal of physiology. Renal physiology, 300(4), F999-1007 (2011-01-14)
Tamm-Horsfall protein (THP) is a glycoprotein expressed exclusively in thick ascending limbs (TAL) of the kidney. We recently described a novel protective role of THP against acute kidney injury (AKI) via downregulation of inflammation in the outer medulla. Our current
Vittoria Esposito et al.
American journal of physiology. Renal physiology, 304(4), F440-F450 (2012-12-14)
C/EBP homologous protein (CHOP) is an important mediator of endoplasmic reticulum (ER) stress-induced cell and organ injury. Here we show that lipopolysaccharide (LPS)-induced acute kidney injury (AKI) is associated with ER stress and elevated CHOP. We postulated that CHOP(-/-) mice
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