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B162

Sigma-Aldrich

B-HT 920 dihydrochloride

solid, ≥98% (HPLC)

Synonym(s):

5,6,7,8-Tetrahydro-6-(2-propenyl)-4H-thiazolo[4,5-d]azepine-2-amine dihydrochloride, Talipexole

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About This Item

Empirical Formula (Hill Notation):
C10H15N3S · 2HCl
CAS Number:
36085-73-1
Molecular Weight:
282.23
MDL number:
MFCD00274573
UNSPSC Code:
12352202
PubChem Substance ID:
24891601

assay

≥98% (HPLC)

form

solid

color

off-white

solubility

H2O: >20 mg/mL

SMILES string

Cl.Cl.Nc1nc2CCN(CCc2s1)CC=C

InChI

1S/C10H15N3S.2ClH/c1-2-5-13-6-3-8-9(4-7-13)14-10(11)12-8;;/h2H,1,3-7H2,(H2,11,12);2*1H

InChI key

DPQAXNSOFFYKDS-UHFFFAOYSA-N

Gene Information

rat ... Drd2(24318)

Biochem/physiol Actions

α2-adrenoceptor agonist; D2 dopamine receptor agonist.

Features and Benefits

This compound is featured on the α2-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
028K4703
014K4702
023K4700

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R C Miller et al.
British journal of pharmacology, 83(4), 903-908 (1984-12-01)
In the presence of endothelium maximal contractions of rat aorta preparations evoked by B-HT 920 were about 10% of those evoked in the absence of endothelium. 6-Allyl-2-amino-5,6,7,8-tetrahydro-4H-thiazolo-(4,5-d)azepin dihydrochloride (B-HT 920, 0.1 microM to 0.1 mM) induced concentration-dependent contractions of rat
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