V116
Z-VAD-FMK
≥98% (TLC), solid, Caspase inhibitor
Synonym(s):
N-Benzyloxycarbonyl-Val-Ala-Asp(O-Me) fluoromethyl ketone
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About This Item
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product name
Z-VAD-FMK, solid
biological source
synthetic
Quality Level
assay
≥98% (TLC)
form
solid
color
white
solubility
DMSO: 20 mg/mL
H2O: insoluble
storage temp.
−20°C
InChI
1S/C22H30FN3O7/c1-13(2)19(26-22(31)33-12-15-8-6-5-7-9-15)21(30)24-14(3)20(29)25-16(17(27)11-23)10-18(28)32-4/h5-9,13-14,16,19H,10-12H2,1-4H3,(H,24,30)(H,25,29)(H,26,31)/t14-,16-,19-/m0/s1
InChI key
MIFGOLAMNLSLGH-QOKNQOGYSA-N
General description
Application
- to induce mixed-lineage kinase domain-like (MLKL) phosphorylation (p-MLKL) in L929 cells[3]
- to induce autophagy in Jurkat and K562 cells[4]
- to revert killing effects of oxaliplatin or oxaliplatin combination with chloroquine (CQ) on HCT116 and SW620 cell lines[5]
- as a caspase inhibitor to inhibit apoptosis and assess nuclear factor-kB, heat shock protein 70 (Hsp 70), proto-oncogene (cmyc) and tumor suppressor protein p53[6]
Biochem/physiol Actions
Features and Benefits
Packaging
Caution
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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