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A2846

Sigma-Aldrich

A-134974 dihydrochloride hydrate

≥98% (HPLC), solid

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Synonym(s):
N7-[(1′R,2′S,3′R,4′S)-2′,3′-dihydroxy-4′-aminocyclopentyl]-4-amino-5-iodopyrrolopyrimidine dihydrochloride hydrate
Empirical Formula (Hill Notation):
C11H14IN5O2 · 2HCl · xH2O
Molecular Weight:
448.09 (anhydrous basis)
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Assay

≥98% (HPLC)

form

solid

storage condition

desiccated

color

off-white to light tan

solubility

H2O: soluble

originator

Abbott

SMILES string

O.Cl.Cl.N[C@H]1C[C@H]([C@H](O)[C@@H]1O)n2cc(I)c3c(N)ncnc23

InChI

1S/C11H14IN5O2.2ClH.H2O/c12-4-2-17(6-1-5(13)8(18)9(6)19)11-7(4)10(14)15-3-16-11;;;/h2-3,5-6,8-9,18-19H,1,13H2,(H2,14,15,16);2*1H;1H2/t5-,6+,8+,9-;;;/m0.../s1

InChI key

INMLNTBMPNIKQK-HWZUHWJPSA-N

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This Item
927082SML1229SML1478
Ni(COD)(Cy-BQ) ≥95%

Sigma-Aldrich

927082

Ni(COD)(Cy-BQ)

Ophiobolin A ≥95% (HPLC)

Sigma-Aldrich

SML1478

Ophiobolin A

form

solid

form

powder

form

powder

form

powder

storage condition

desiccated

storage condition

-

storage condition

-

storage condition

protect from light

color

off-white to light tan

color

-

color

white to beige

color

white to beige

solubility

H2O: soluble

solubility

-

solubility

-

solubility

-

originator

Abbott

originator

-

originator

-

originator

-

Biochem/physiol Actions

A-134974 is a novel and selective adenosine kinase (AK) inhibitor with IC50 = 60 pM. Systemic A-134974 (i.p.) dose dependently reduced hyperalgesia (ED50= 1 μmol/kg) and at higher doses, reduced locomotor activity (ED50 = 16 μmol/kg). Administration of A-134974 intrathecally (i.t.) was more potent (ED50= 6 nmol) at producing antihyperalgesia than delivering the compound by intracerebralventricular (ED50 = 100 nmol, i.c.v.) or intraplantar (ED50 >300 nmol) routes. In contrast, i.c.v. administration of A-134974 was more effective in reducing locomotor activity than i.t. administration (ED50 values were 1 and >100 nmol, respectively). Increasing the pretreatment time for i.t.-delivered A-134974 caused a greater reduction in locomotor activity (ED50= 10 nmol). This was due to diffusion of A-134974 (i.t.) to supraspinal sites. These data demonstrate that the novel AK inhibitor A-134974 potently reduces thermal hyperalgesia primarily through interactions with spinal sites, whereas its ability to depress locomotor activity is predominantly mediated by supraspinal sites.

Features and Benefits

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

Sold under license from Abbott Laboratories.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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