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A4352

Sigma-Aldrich

Anti-phospho-AMPA Receptor, GluR1 Subunit (pSer831) antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

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Synonym(s):
Anti-phospho-AMPA Glutamate Receptor 1 (pSer831)
MDL number:
NACRES:
NA.41

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 100 kDa

species reactivity

rat, human

concentration

~1 mg/mL

technique(s)

direct ELISA: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: 1:1,000 using rat brain (hippocampal) homogenate

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pSer831)

Gene Information

human ... GRIA1(2890)
rat ... Gria1(50592)

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This Item
A4477M2442ABN241
vibrant-m

ABN241

Anti-GluR1 Antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

biological source

rabbit

biological source

rabbit

biological source

rabbit

biological source

rabbit

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

100

Gene Information

human ... GRIA1(2890)
rat ... Gria1(50592)

Gene Information

human ... GRIA1(2890)
rat ... Gria1(50592)

Gene Information

human ... GRIN2B(2904)
mouse ... Grin2b(14812)
rat ... Grin2b(24410)

Gene Information

human ... GRIA1(2890)
mouse ... Gria1(14799)
rat ... Gria1(50592)

species reactivity

rat, human

species reactivity

human, rat

species reactivity

mouse, rat, Xenopus, chicken, human

species reactivity

human, mouse, rat

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General description

AMPA is a transmembrane receptor for glutamate that regulates synapsis in the central nervous system. It is composed of 4 types of subunits, GluR1, 2, 3, 4.
GluR1 subunits of AMPA receptors are membrane proteins that regulate synaptic plasticity of the central nervous system. This receptor has also been implicated in spatial memory retention. Phosphorylation of serine 831 in GluR1 subunit of the AMPA receptor modulates long-term potentiation in neuronal synapses. Anti-phospho-AMPA Receptor, GluR1 Subunit (pSer831) antibody is specific for the GluR1 subunit (phosphorylated on serine 831) of the AMPA receptor in rats and humans.

Immunogen

The GluR1 sequence is conserved among species and has partial homology to VGLUT2.
synthetic phosphopeptide corresponding to a region near serine 831 of rat glutamate receptor subunit GluR1.

Application

Anti-phospho-AMPA Receptor, GluR1 Subunit (pSer831) antibody is suitable for use in direct ELISA, immunohistochemistry, immunoblot and immunoprecipitation. The antibody may also be used for western blot (1:1,000 using rat hippocampal homogenate).

Physical form

Solution in 10 mM HEPES buffer, pH 7.5, containing 150 mM NaCl, 100 μg/ml BSA and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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Rodrigo Bainy Leal et al.
Molecular psychiatry, 25(3), 655-665 (2018-06-09)
Fear is a conscious state caused by exposure to real or imagined threats that trigger stress responses that affect the body and brain, particularly limbic structures. A sub-group of patients with mesial temporal lobe epilepsy related to hippocampus sclerosis (MTLE-HS)
Hey-Kyoung Lee et al.
Journal of neurophysiology, 103(1), 479-489 (2009-11-13)
Activity-dependent changes in excitatory synaptic transmission in the CNS have been shown to depend on the regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs). In particular, several lines of evidence suggest that reversible phosphorylation of AMPAR subunit glutamate receptor 1 (GluR1
Hey-Kyoung Lee et al.
Cell, 112(5), 631-643 (2003-03-12)
Plasticity of the nervous system is dependent on mechanisms that regulate the strength of synaptic transmission. Excitatory synapses in the brain undergo long-term potentiation (LTP) and long-term depression (LTD), cellular models of learning and memory. Protein phosphorylation is required for
Promotion of bone cancer pain development by decorin is accompanied by modification of excitatory synaptic molecules in the spinal cord.
Huan Wang et al.
Molecular pain, 15, 1744806919864253-1744806919864253 (2019-07-02)
Xiang Cai et al.
Nature neuroscience, 16(4), 464-472 (2013-03-19)
The causes of major depression remain unknown. Antidepressants elevate concentrations of monoamines, particularly serotonin, but it remains uncertain which downstream events are critical to their therapeutic effects. We found that endogenous serotonin selectively potentiated excitatory synapses formed by the temporoammonic

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