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A4978

Sigma-Aldrich

Alendronate sodium trihydrate

≥97% (NMR), powder

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Synonym(s):
4-amino-1-hydroxy-1-phosphonobutyl phosphonic acid, monosodium, MK-217
Empirical Formula (Hill Notation):
C4H12NaNO7P2 · 3 H2O
CAS Number:
Molecular Weight:
325.12
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Quality Level

assay

≥97% (NMR)

form

powder

color

white

solubility

water, double-distilled: 10 mg/mL

storage temp.

−20°C

SMILES string

[Na+].[H]O[H].[H]O[H].[H]O[H].NCCCC(O)(P(O)(O)=O)P(O)([O-])=O

InChI

1S/C4H13NO7P2.Na.3H2O/c5-3-1-2-4(6,13(7,8)9)14(10,11)12;;;;/h6H,1-3,5H2,(H2,7,8,9)(H2,10,11,12);;3*1H2/q;+1;;;/p-1

InChI key

DCSBSVSZJRSITC-UHFFFAOYSA-M

Gene Information

human ... FDPS(2224)

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This Item
1012780I5784Y0001727
Alendronate sodium trihydrate ≥97% (NMR), powder

A4978

Alendronate sodium trihydrate

Alendronate sodium United States Pharmacopeia (USP) Reference Standard

1012780

Alendronate sodium

Ibandronate sodium salt ≥97% (NMR), solid

I5784

Ibandronate sodium salt

Sodium alendronate trihydrate European Pharmacopoeia (EP) Reference Standard

Y0001727

Sodium alendronate trihydrate

form

powder

form

-

form

solid

form

-

storage temp.

−20°C

storage temp.

-

storage temp.

2-8°C

storage temp.

2-8°C

solubility

water, double-distilled: 10 mg/mL

solubility

-

solubility

H2O: >10 mg/mL

solubility

-

color

white

color

-

color

white

color

-

Gene Information

human ... FDPS(2224)

Gene Information

human ... FDPS(2224)

Gene Information

human ... FDPS(2224)

Gene Information

human ... FDPS(2224)

Application

Alendronate sodium trihydrate has been used:
  • for calcium phosphate nanoparticles (nCaP)/ bisphosphonate (BP) coating on titanium implants and analyze its osteogenic capacity
  • in osteogenic differentiation of human bone marrow stromal cells (hBMSCs) isolated from aged osteoporosis patients- and healthy-person
  • to treat osteoblast progenitor cells and osteoblasts and study their effect on osteoblast behaviors using conventional assays and simple digital image analysis

Biochem/physiol Actions

Alendronate is a nitrogen-containing bisphosphonate that is known to hinder the mevalonate pathway and limit osteoclastic function and activity. Alendronate sodium trihydrate is a bone resorption inhibitor, farnesyl diphosphate synthase inhibitor, and CD45 protein tyrosine phosphatase inhibitor.
Alendronate sodium trihydrate is a bone resorption inhibitor; farnesyl diphosphate synthase inhibitor (IC50 = 460 nM); CD45 protein tyrosine phosphatase inhibitor.

Storage and Stability

Following reconstitution, it is recommended to aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C.

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


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