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AV41388

Sigma-Aldrich

Anti-SLC12A1 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-BSC1, Anti-MGC48843, Anti-NKCC2, Anti-Solute carrier family 12 (sodium/potassium/chloride transporters), member 1

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100 ML
$156.00
500 ML
$676.00

$156.00

Available to ship onApril 03, 2025Details

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100 ML
$156.00
500 ML
$676.00

About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

$156.00

Available to ship onApril 03, 2025Details

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

47 kDa

species reactivity

rabbit, rat, human, mouse, pig, dog, bovine, horse

concentration

0.5 mg - 1 mg/mL

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300

Quality Level

100

bp

314.4 +/- 5.0 °C/760 mmHg (lit.), 314.4 °C±5.0 °C/760 mmHg (lit.), 179 °C/15 mmHg (lit.)

bp

179 °C/15 mmHg (lit.), 314.4 °C±5.0 °C/760 mmHg (lit.)

bp

179 °C/15 mmHg (lit.), 314.4 °C±5.0 °C/760 mmHg (lit.)

bp

314.4 +/- 5.0 °C/760 mmHg (lit.), 179 °C/15 mmHg (lit.), 314.4 °C±5.0 °C/760 mmHg (lit.)

refractive index

n20/D 1.444 (lit.), n20/D 1.445

refractive index

n20/D 1.444 (lit.), n20/D 1.445

refractive index

n20/D 1.444 (lit.)

refractive index

n20/D 1.444 (lit.)

form

liquid

form

-

form

-

form

-

density

0.789 g/mL at 25 °C (lit.)

density

0.789 g/mL at 25 °C (lit.)

density

0.789 g/mL at 25 °C (lit.)

density

0.789 g/mL at 25 °C (lit.)

Immunogen

Synthetic peptide directed towards the N terminal region of human SLC12A1

Biochem/physiol Actions

The sodium-potassium-chloride cotransporter isoform 2 is kidney-specific and is found on the apical membrane of the thick ascending limb of Henle′s loop and the macula densa. It accounts for most of the NaCl resorption with the stoichiometry of 1Na:1K:2Cl and is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene.

Sequence

Synthetic peptide located within the following region: NEKKSRGFFNYQASIFAENFGPRFTKGEGFFSVFAIFFPAATGILAGANI

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

  • Specification Sheet

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    Certificates of Analysis (COA)

    Lot/Batch Number
    QC12072

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    Peter Fickert et al.
    Hepatology (Baltimore, Md.), 58(6), 2056-2069 (2013-07-03)
    Tubular epithelial injury represents an underestimated but important cause of renal dysfunction in patients with cholestasis and advanced liver disease, but the underlying mechanisms are unclear. To address the hypothesis that accumulation and excessive alternative urinary elimination of potentially toxic

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