MilliporeSigma
All Photos(1)

Documents

C0913

Sigma-Aldrich

Complement C2 deficient serum human

for complement assays

All Photos(1)
CAS Number:
80295-40-5
MDL number:
MFCD00130835
NACRES:
NA.61

biological source

human

Quality Level

200

form

liquid

technique(s)

activity assay: suitable

UniProt accession no.

P06681

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... C2(717)

Related Categories

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
C1288C2787C1163
Sigma-Aldrich

Sigma-Aldrich

C0913

Complement C2 deficient serum human

Sigma-Aldrich

Sigma-Aldrich

C1288

Complement C6 deficient serum human

Sigma-Aldrich

Sigma-Aldrich

C2787

Complement C7 from human serum

Sigma-Aldrich

Sigma-Aldrich

C1163

Complement C5 deficient serum human

form

liquid

form

liquid

form

solution

form

solution

technique(s)

activity assay: suitable

technique(s)

activity assay: suitable

technique(s)

activity assay: suitable

technique(s)

activity assay: suitable

UniProt accession no.

P06681

UniProt accession no.

P13671

UniProt accession no.

P10643

UniProt accession no.

P01031

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

shipped in

-

storage temp.

−70°C

storage temp.

−70°C

storage temp.

−70°C

storage temp.

−70°C

Application

C2 is a critical protease for compliment activation, which supports bacterial killing via phagocytes. C2 can be used in research to explore the mechanisms by which bacterial pathogens evade detection by the compliment system. One such mechanism by the bacteria Pseudomonas aeruginosa, uses the alkaline protease (AprA) to degrade and cleave C2 which ultimately interferes with the classical and lectin pathways. Research has shown that C2 deficiency results in an increased risk of infection by Streptococcus pyogenes through impaired phaogocytosis and neutrophil dependent killing.

Biochem/physiol Actions

Heritable complement C2 deficiency can manifest as a number of severe dermatological disorders, including discoid lupus erythematosus, idiopathic atrophoderma, and dermatomyositis.

Physical form

Supplied as a solution in PBS, pH 7.2

Analysis Note

C2 is depleted by immunoadsorption method as judged by a highly sensitive hemolytic assay and Ouchterlony immunodiffusion method.

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Documents related to the products that you have purchased in the past have been gathered in the Document Library for your convenience.

Visit the Document Library

Difficulty Finding Your Product Or Lot/Batch Number?

Product numbers are combined with Pack Sizes/Quantity when displayed on the website (example: T1503-25G). Please make sure you enter ONLY the product number in the Product Number field (Example: T1503).

Example:

T1503
Product Number
-
25G
Pack Size/Quantity

Additional examples:

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

enter as 1.000309185)

Having trouble? Feel free to contact Technical Service for assistance.

Lot and Batch Numbers can be found on a product's label following the words 'Lot' or 'Batch'.

Aldrich Products

  • For a lot number such as TO09019TO, enter it as 09019TO (without the first two letters 'TO').

  • For a lot number with a filling-code such as 05427ES-021, enter it as 05427ES (without the filling-code '-021').

  • For a lot number with a filling-code such as STBB0728K9, enter it as STBB0728 without the filling-code 'K9'.

Not Finding What You Are Looking For?

In some cases, a COA may not be available online. If your search was unable to find the COA you can request one.

Request COA

Pseudomonas aeruginosa Alkaline Protease Blocks Complement Activation via the Classical and Lectin Pathways.
Laarman AJ., et al.
Journal of Immunology (2011)
J P Leddy et al.
The American journal of medicine, 58(1), 83-91 (1975-01-01)
A 60 year old white man in previous good health presented with a 6 month history of progressive muscle weakness. Clinical and laboratory findings were typical of dermatomyositis. Muscle biopsy confirmed the presence of inflammatory myopathy; deposits of immunoglobulin G
Miki Nakao et al.
Developmental and comparative immunology, 26(6), 533-541 (2002-05-29)
Complement factor B and C2 are two critical proteases for complement activation. Some bony fish have been reported to possess duplicated genes for B/C2, but there is no direct evidence regarding possible functional divergence. Here, we report the isolation of
Cryo-EM structures of Trypanosoma brucei gambiense ISG65 with human complement C3 and C3b and their roles in alternative pathway restriction.
S??lzen, et al.
Nature Communications, 14, 2403-2403 (2023)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service