C2365
Clofilium tosylate
>97%, solid
Synonym(s):
4-Chloro-N,N-diethyl-N-heptylbenzenebutanaminium tosylate
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About This Item
Empirical Formula (Hill Notation):
C21H37ClN · C7H7O3S
CAS Number:
Molecular Weight:
510.17
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Recommended Products
Quality Level
assay
>97%
form
solid
color
white
solubility
H2O: soluble
SMILES string
Cc1ccc(cc1)S([O-])(=O)=O.CCCCCCC[N+](CC)(CC)CCCCc2ccc(Cl)cc2
InChI
1S/C21H37ClN.C7H8O3S/c1-4-7-8-9-11-18-23(5-2,6-3)19-12-10-13-20-14-16-21(22)17-15-20;1-6-2-4-7(5-3-6)11(8,9)10/h14-17H,4-13,18-19H2,1-3H3;2-5H,1H3,(H,8,9,10)/q+1;/p-1
InChI key
MOQZYUUHIWPDQC-UHFFFAOYSA-M
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Biochem/physiol Actions
K+ channel blocker; cardiac depressant; anti-arrhythmic
Features and Benefits
This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
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Clofilium and other class III agents.
Steinberg, et al. et al.
Handbook of Experimental Pharmacology, 89, 389-389 (1989)
W B Gough et al.
Cardiovascular research, 23(6), 554-559 (1989-06-01)
To determine whether ischaemic tissue is more sensitive than normal tissue to class III anti-arrhythmic agents, we studied the effects of the class III agents clofilium, d-sotalol and bretylium on normal and ischaemic Purkinje fibres one day after ligation of
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