D1414

Droperidol

dopamine subtype 2 receptor antagonist, powder

• Synonym(s): 1-[1-[3-(p-Fluorobenzoyl)propyl]-1,2,3,6-tetrahydro-4-pyridyl]-2-benzimidazolinone
• Empirical Formula (Hill Notation): C₂₂H₂₂FN₃O₂
• CAS Number: 548-73-2
• Molecular Weight: 379.43
• NACRES: NA.77
• PubChem Substance ID: 24278357
• UNSPSC Code: 41116107
• EC Number: 208-957-8
• MDL number: MFCD00083290
• Form: powder
• Quality level: 200

Properties

• Product Name: Droperidol,
• form: powder
• Quality Level: 200
• originator: Johnson & Johnson
• storage temp.: 2-8°C
• SMILES string: Fc1ccc(cc1)C(=O)CCCN2CCC(=CC2)N3C(=O)Nc4ccccc34
• InChI: 1S/C22H22FN3O2/c23-17-9-7-16(8-10-17)21(27)6-3-13-25-14-11-18(12-15-25)26-20-5-2-1-4-19(20)24-22(26)28/h1-2,4-5,7-11H,3,6,12-15H2,(H,24,28)
• InChI key: RMEDXOLNCUSCGS-UHFFFAOYSA-N
• Gene Information: human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), HTR2A(3356), KCNH1(3756), KCNH2(3757)

Description

Biochem/physiol Actions

D₁, D₂ dopamine receptor antagonist; butyrophenone antipsychotic and anti-emetic.

Droperidol is a potent antagonist of dopamine subtype 2 receptor. It is an antipsychotic, which is used to treat acute behavioral anomalies. It helps to manage postoperative nausea and vomiting.

Features and Benefits

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P301 + P312 + P330
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves