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D4010

Sigma-Aldrich

2′-Deoxyguanosine 5′-triphosphate sodium salt hydrate

≥96% (HPLC)

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Synonym(s):
2′-deoxy-, 5′-triphosphate sodium salt, Guanosine, dGTP sodium salt hydrate
Empirical Formula (Hill Notation):
C10H16N5O13P3 · xNa+ · yH2O
CAS Number:
Molecular Weight:
507.18 (anhydrous free acid basis)
PubChem Substance ID:
NACRES:
NA.51

biological source

synthetic (organic)

Quality Level

assay

≥96% (HPLC)

form

powder

shipped in

dry ice

storage temp.

−20°C

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Application

2′-Deoxyguanosine 5′-triphosphate sodium salt hydrate has been used:
  • as a component in a polymerase chain reaction (PCR) mixture for PCR product formation using AM-toxin primers
  • as an internal standard to improve the analytical performance of capillary electrophoresis (CE) analysis for the evaluation of the cleanup process
  • as a putative substrate in in vitro enzyme activity assay to incubate with nudix hydrolase 15 (NUDT15) protein for the evaluation of putative NUDT15 inhibitors

Biochem/physiol Actions

Deoxyguanosine 5′-triphosphate (dGTP), a purine deoxynucleotide, is a substrate of DNA polymerase(s) and reverse transcriptases. dGTP is useful to study the distribution, specificity, and kinetics of various nucleoside-triphosphatases (NTPase) and ribonucleotide reductases.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

ppe

Eyeshields, Gloves, type N95 (US)


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