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EHU092281

Sigma-Aldrich

MISSION® esiRNA

targeting human VPS13A

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NACRES:
NA.51

description

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Quality Level

product line

MISSION®

form

lyophilized powder

esiRNA cDNA target sequence

TTCACTGAAGATCCAAGGGTATTTAAAGTAACATATGAAAGTGAGAAAGCAGAGTTAGCAGAGCAAGAAATTGCAGTGGCATTACAAGATGTTGGAATTTCTCTTGTCAACAATTACACGAAGCAAGAAGTAGCCTATATAGGCATTACAAGTTCTGATGTGGTTTGGGAAACAAAGCCCAAGAAGAAGGCAAGATGGAAGCCAATGAGTGTAAAGCACACTGAGAAGTTAGAGAGAGAATTTAAGGAATATACTGAATCTTCTCCTTCAGAAGATAAGGTTATTCAGTTGGACACTAATGTTCCGGTTCGCCTAACCCCTACTGGTCATAACATGAAAATTCTGCAGCCGCATGTAATAGCTCTACGAAGAAATTATCTTCCAGCATTAAAAGTGGAATATAACACATCTGCACATCAATCATC

Ensembl | human accession no.

NCBI accession no.

shipped in

ambient

storage temp.

−20°C

Gene Information

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MISSION® esiRNA targeting human VPS13A

EHU092281

MISSION® esiRNA

MISSION® esiRNA targeting human VPS13C

EHU061911

MISSION® esiRNA

MISSION® esiRNA targeting human VPS13B

EHU086001

MISSION® esiRNA

MISSION® esiRNA targeting human VPS33A

EHU016571

MISSION® esiRNA

esiRNA cDNA target sequence

TTCACTGAAGATCCAAGGGTATTTAAAGTAACATATGAAAGTGAGAAAGCAGAGTTAGCAGAGCAAGAAATTGCAGTGGCATTACAAGATGTTGGAATTTCTCTTGTCAACAATTACACGAAGCAAGAAGTAGCCTATATAGGCATTACAAGTTCTGATGTGGTTTGGGAAACAAAGCCCAAGAAGAAGGCAAGATGGAAGCCAATGAGTGTAAAGCACACTGAGAAGTTAGAGAGAGAATTTAAGGAATATACTGAATCTTCTCCTTCAGAAGATAAGGTTATTCAGTTGGACACTAATGTTCCGGTTCGCCTAACCCCTACTGGTCATAACATGAAAATTCTGCAGCCGCATGTAATAGCTCTACGAAGAAATTATCTTCCAGCATTAAAAGTGGAATATAACACATCTGCACATCAATCATC

esiRNA cDNA target sequence

TGTGCAGGAGACTGTAAGAGTGAGAAAAGTTGATGTTTCAAGTGTACCTGACCATCTCAAAGAACAAGAAGATTGGACAGACTCAAAGCTCTCTATGAACCAGATTGTCAGTCTCCAATTTGACTTTCACTTTGAATCTCTTTCCATTATCCTTTATAACAATGATATCAACCAGGAATCTGGAGTTGCATTTCATAATGACAGTTTCCAACTTGGTGAACTCAGACTACATCTTATGGCCTCCTCAGGGAAGATGTTTAAGGATGGCTCAATGAATGTCAGCGTTAAACTTAAGACATGCACCCTTGATGATCTCAGAGAAGGAATTGAGAGAGCAACATCGAGAATGATTGACAGAAAGAATGACCAAGATAACAACAGTTCTATGATTGATATAAGTTACAAACAAGACAAAAATGGAAGTCAAATTGATGCTGTTCTTGACAAGCTGTATGTATGTGCCAGTGTGGAATTTCT

esiRNA cDNA target sequence

CCTGCTCAGCATAAAGGTCAAGAGTTATATTCACAGCAAGATGAGGAGCAGCCACAGGGATGGGTGTCATGGGCCTGGTCCTTTGTGCCTGCAATTGTGAGTTATGACGATGGCGAGGAAGACTTTGTTGGGAACGATCCTGCATCAACCATGCATCAACAAAAAGCACAGACTTTGAAGGATCCTATTGTTTCTATAGGATTTTATTGCACAAAGGCAACGGTGACTTTCAAACTCACAGAAATGCAAGTTGAGAGTAGTTATTACAGTCCACAGAAAGTAAAATCTAAAGAAGTATTGTGTTGGGAACAAGAAGGAACTACAGTTGAGGCCCTTATGATGGGAGAACCTTTCTTTGATTGCCAGATTGGGTTTGTTGGTTGCAGAGCCATGTGCCTTAA

esiRNA cDNA target sequence

GCAAGTGGCCAATATGATGATCAGGATGAAGAGAGAGTTTACAGGAAGCCAGAATTCAATATTTCCTGTTTTTGATAATCTCTTGTTGCTTGATCGGAATGTGGATTTATTAACACCTCTTGCCACTCAGCTGACATATGAAGGACTCATTGATGAAATTTATGGCATTCAGAACAGTTATGTGAAATTACCTCCAGAGAAATTTGCACCTAAGAAACAGGGCGATGGTGGTAAGGACCTCCCCACGGAAGCAAAGAAGCTGCAGCTGAATTCTGCAGAGGAGCTCTATGCTGAGATCCGAGATAAGAACTTCAACGCAGTTGGCTCTGTGCTCAGCAAGAAAGCAAAGATCATCTCTGCAGCATTCGAGGAAAGACACAATGCTAAGACCGTGGGGGAGATCAAGCAGTTTGTTTCCCAGTTGCC

Ensembl | human accession no.

ENSG00000197969

Ensembl | human accession no.

ENSG00000129003

Ensembl | human accession no.

ENSG00000132549

Ensembl | human accession no.

ENSG00000139719

product line

MISSION®

product line

MISSION®

product line

MISSION®

product line

MISSION®

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

General description

MISSION esiRNA are endoribonuclease prepared siRNA. They are a heterogeneous mixture of siRNA that all target the same mRNA sequence. These multiple silencing triggers lead to highly-specific and effective gene silencing.

For additional details as well as to view all available esiRNA options, please visit SigmaAldrich.com/esiRNA.

Legal Information

MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable


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Willi Yu et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 40(5), 1141-1152 (2016-12-14)
Chorein, a protein encoded by VPS13A (vacuolar protein sorting-associated protein 13A), is defective in chorea acanthocytosis, a rare disease characterized by acanthocytosis of red blood cells and neuronal cell death with progressive hyperkinetic movement disorder, cognitive dysfunction, behavioral abnormalities and
Sandra Muñoz-Braceras et al.
Disease models & mechanisms, 12(2) (2019-02-03)
Members of the VPS13 family are associated with various human diseases. In particular, the loss of function of VPS13A leads to chorea-acanthocytosis (ChAc), a rare neurodegenerative disease without available curative treatments. Autophagy has been considered a promising therapeutic target because
Sabina Honisch et al.
Oncotarget, 6(12), 10309-10319 (2015-04-15)
Chorein encoded by VPS13A (vacuolar protein sorting-associated protein 13A) is defective in chorea-acanthocytosis. Chorein fosters neuronal cell survival, cortical actin polymerization and cell stiffness. In view of its anti-apoptotic effect in neurons, we explored whether chorein is expressed in cancer

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