F5386

Fibrin from human plasma

insoluble powder

• CAS Number: 9001-31-4
• EC Number: 232-597-0
• MDL number: MFCD00131058
• NACRES: NA.61

Properties

• biological source: human plasma
• Quality Level: 200
• form: powder
• technique(s): indirect ELISA: suitable
• UniProt accession no.: P02671; P02675; P02679
• InChI: 1S/C5H11N3O2/c1-7-5(10)3-8-4(9)2-6/h2-3,6H2,1H3,(H,7,10)(H,8,9)
• InChI key: BWGVNKXGVNDBDI-UHFFFAOYSA-N
• Gene Information: human ... FGA(2243) , FGB(2244) , FGG(2266)

Description

General description

Fibrin is produced from cross-linking of fibrinogen by thrombin. Fibrinogen is made up of two monomers each containing three polypeptide chains. Fibrinogen is a major plasma protein.

Application

Fibrin from human plasma has been used:

• for in vitro cleavage of fibrinogen and fibrin
• as a reference for true component analysis (TCA) and principal component analysis (PCA) of Raman spectra
• as a reference in Raman spectroscopy to study the binding mechanisms and the binding efficiency of the different polyoxometalates (POMs)

Biochem/physiol Actions

Fibrin acts as an important bio-polymer in the primary blood clotting process. It creates a scaffold for infiltrating cells during tissue repair. Fibrin is widely used as a tissue sealant for tissue regeneration applications as it enables the formation of a biocompatible physical structure. It is also used in delivery systems for cells and bioactive molecules. The fibrin matrix resembles the native pancreas and can serve as a scaffold material for islet transplantation. Fibrin has been used in studies to obtain fibrin-specific monoclonal antibodies (mAbs). These mAbs may be used to determine their role in fibrin polymerization and use in fibrin quantification in blood plasma.

Preparation Note

Prepared by clotting fibrinogen to yield a crosslinked fibrin

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable