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G5146

Sigma-Aldrich

D-(+)-Glucose

Hybri-Max, powder, BioReagent, suitable for hybridoma

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Synonym(s):
Dextrose
Empirical Formula (Hill Notation):
C6H12O6
CAS Number:
Molecular Weight:
180.16
Beilstein/REAXYS Number:
1724615
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.75

biological source

maize

grade

Hybri-Max

product line

BioReagent

assay

≥99.5%

form

powder

technique(s)

cell culture | hybridoma: suitable

impurities

endotoxin, tested

mp

150-152 °C (lit.)

solubility

H2O: 2g + 15 mL (Tested)

SMILES string

OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O

InChI

1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6+/m1/s1

InChI key

WQZGKKKJIJFFOK-DVKNGEFBSA-N

Gene Information

human ... PYGM(5837)

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1 of 4

This Item
G8270G7021G7528
vibrant-m

G5146

D-(+)-Glucose

-
vibrant-m

G8270

D-(+)-Glucose

-
vibrant-m

G7021

D-(+)-Glucose

-
vibrant-m

G7528

D-(+)-Glucose

Premium Grade
grade

Hybri-Max

grade

-

grade

-

grade

-

biological source

maize

biological source

maize

biological source

-

biological source

maize

solubility

H2O: 2g + 15 mL (Tested)

solubility

H2O: 2g + 15 mL (Tested)

solubility

H2O: 2g + 15 mL (Tested)

solubility

H2O: 1 M

technique(s)

cell culture | hybridoma: suitable

technique(s)

gas chromatography (GC): suitable

technique(s)

cell culture | insect: suitable, cell culture | mammalian: suitable, cell culture | plant: suitable

technique(s)

gas chromatography (GC): suitable

assay

≥99.5%

assay

≥99.5% (GC)

assay

≥99.5%

assay

≥99.5% (GC)

General description

Glycogen phosphorylase (PYG) exists as brain and muscle isoform. It is expressed in astrocytes and neurons respectively. The PYGM gene is mapped to human chromosome 11q13.1.

Application

D-(+)-Glucose has been used in cell engineering. It has also been used to perform oral glucose tolerance test.

Biochem/physiol Actions

Glycogen phosphorylase, muscle associated (PYGM), is an important contributor to glycogenolysis. Down regulation of PYGM gene is observed in schizophrenia. Mutation in PYGM leads to McArdle disease, a glycogen storage disorder. The PYGM gene is significantly associated with energy production.

Preparation Note

The material may produce a yellowish solution if prepared at a higher concentration than 2g + 15ml.

Legal Information

Hybri-Max is a trademark of Sigma-Aldrich Co. LLC

related product

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

ppe

Eyeshields, Gloves, type N95 (US)


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25G
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Genetic evaluation of AMPD1, CPT2, and PGYM metabolic enzymes in patients with chronic fatigue syndrome
Maltese PE, et al.
Genetics and molecular research : GMR, 15(3), 1-10 (2016)
Novel variant in the PYGM gene causing late-onset limb-girdle myopathy, ptosis, and camptocormia
Cheraud C, et al.
Muscle and Nerve, 57(1), 157-160 (2018)
Electrical vs manual acupuncture stimulation in a rat model of polycystic ovary syndrome: different effects on muscle and fat tissue insulin signaling
Johansson J, et al.
PLoS ONE, 8(1) (2013)
Comparative metabolic analysis of CHO cell clones obtained through cell engineering, for IgG productivity, growth and cell longevity
Wilkens CA and Gerdtzen ZP
PLoS ONE, 10(3) (2015)
CDKN1C/p57 kip2 is a candidate tumor suppressor gene in human breast cancer
Larson PS, et al.
BMC Cancer, 8(1), 68-68 (2008)

Articles

We presents an article about the Warburg effect, and how it is the enhanced conversion of glucose to lactate observed in tumor cells, even in the presence of normal levels of oxygen. Otto Heinrich Warburg demonstrated in 1924 that cancer cells show an increased dependence on glycolysis to meet their energy needs, regardless of whether they were well-oxygenated or not.

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