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MilliporeSigma

G8146

Sigma-Aldrich

Disialoganglioside GD1b from bovine brain

~95%, lyophilized powder

Synonym(s):

Ganglioside GD1b, disialo

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500 G
$385.00
1 KG
$705.00

$385.00


Estimated to ship onMarch 28, 2025


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500 G
$385.00
1 KG
$705.00

About This Item

CAS Number:
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77

$385.00


Estimated to ship onMarch 28, 2025


Request a Bulk Order

assay

~95%

Quality Level

form

lyophilized powder

storage temp.

−20°C

InChI

1S/C80H144N4O37/c1-4-6-8-10-12-14-16-18-19-21-23-25-27-29-31-33-54(96)83-36-49(44(91)32-30-28-26-24-22-20-17-15-13-11-9-7-5-2)111-74-65(104)63(102)67(52(40-88)114-74)116-76-66(105)72(68(53(41-89)115-76)117-73-57(84-43(3)90)71(61(100)51(39-87)112-73)118-75-64(103)62(101)60(99)50(38-86)113-75)121-80(78(108)109)35-46(93)56(82)70(120-80)59(98)48(95)42-110-79(77(106)107)34-45(92)55(81)69(119-79)58(97)47(94)37-85/h30,32,44-53,55-76,85-89,91-95,97-105H,4-29,31,33-42,81-82H2,1-3H3,(H,83,96)(H,84,90)(H,106,107)(H,108,109)/b32-30+/t44?,45-,46+,47?,48?,49?,50+,51+,52-,53+,55+,56-,57+,58?,59?,60-,61-,62-,63-,64+,65-,66+,67-,68-,69+,70-,71+,72+,73-,74-,75-,76-,79-,80-/m1/s1

InChI key

AIUBMTQAHKTQMI-MPGPKOMUSA-N

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Amino Acid Sequence

Cer-Glc-Gal(NeuAc-NeuAc)-GalNAc-Gal

General description

Gangliosides are major constituents of neuronal cell membranes and endoplasmic reticulum; contain a sialated polysaccharide chain linked to ceramide through a β-glycosidic linkage; for classification of gangliosides see Svennerholm, L., et al. (eds.), Structure and Function of Gangliosides, New York, Plenum, 1980.

Biochem/physiol Actions

May act as a bacterial toxin receptor (tetanus, botulinus); high levels found in gliomas and astrocytomas.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Customers Also Viewed

S Attarian et al.
Journal of neurology, neurosurgery, and psychiatry, 81(1), 61-64 (2009-09-04)
To determine the responses to treatment of patients with chronic sensory ataxic neuropathy associated with anti-GD1b IgM antibodies. Patients with chronic sensory ataxic neuropathy associated with anti-GD1b IgM antibodies followed in our department for at least 12 months between 2001
An unusual presentation of Guillain-Barré syndrome associated with monospecific anti-GD1b antibodies.
Maarten Dewil et al.
Journal of neurology, neurosurgery, and psychiatry, 81(5), 587-588 (2010-05-13)
S Tellier et al.
Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 19(1), 51-54 (2011-12-14)
We describe the case of a 10-year-old child with the acute motor axonal neuropathy (AMAN) form of Guillain-Barré syndrome (GBS) with preserved tendon reflexes, 6 days after a bout of gastroenteritis. The child quickly showed weakness of the distal muscles
Beatriz Valle-Argos et al.
Neuro-oncology, 12(11), 1135-1146 (2010-07-10)
In spite of their low incidence, central nervous system tumors have elevated morbidity and mortality, being responsible for 2.3% of total cancer deaths. The ganglioside O-acetylated GD1b (O-Ac GD1b; neurostatin), present in the mammalian brain, and the semi-synthetic O-butyrylated GD1b
Ana L Moyano et al.
Glycobiology, 22(12), 1768-1774 (2012-07-31)
Immunization of rabbits with bovine brain gangliosides induced an experimental neuropathy, with clinical signs resembling Guillain-Barré syndrome. All the immunized animals developed immunoglobulin G immunoreactivity to GM1 ganglioside. In a few (4 of 27) animals, an additional anti-ganglioside antibody population

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