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GW22829

Sigma-Aldrich

Anti-PSMC5 antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

chicken

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human, rat

manufacturer/tradename

Genway 15-288-22829

technique(s)

western blot: suitable

NCBI accession no.

NP_002796.4

UniProt accession no.

P62195

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... PSMC5(5705)

Related Categories

General description

PSMC5 (proteasome 26S subunit, ATPase, 5) is a regulatory subunit of the 26S proteasome belonging to the family of putative ATPases. It has structural homology with yeast Sug1p gene.

Immunogen

Immunogen Sequence: GI # 24497435, sequence 2-160
Recombinant proteasome 26S ATPase subunit 5

Application

Anti-PSMC5 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem/physiol Actions

26S protease regulatory subunit 8 is an enzyme encoded by the PSMC5 gene in humans and is important for the transcription of MHC II molecules. It has a role in regulating transcription of class I MHC and the MHC II-like molecules, HLA-DM and HLA-DO. PSMC5 acts as a key regulator of collagen contraction in primary human lung fibroblasts (a functional characteristic of myofibroblasts) and is a critical step in the process of fibrosis.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificates of Analysis (COA)

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Michael F Nyp et al.
Respiratory research, 15, 19-19 (2014-02-18)
Myofibroblasts are the critical effector cells in the pathogenesis of pulmonary fibrosis which carries a high degree of morbidity and mortality. We have previously identified Type II TGFβ receptor interacting protein 1 (TRIP-1), through proteomic analysis, as a key regulator
Yaritza Inostroza-Nieves et al.
Immunology letters, 147(1-2), 67-74 (2012-07-10)
The 19S proteasome regulatory particle plays a critical role in cellular proteolysis. However, emerging evidence suggests roles for 19S proteasome subunits in regulating yeast and mammalian transcription. It has been previously shown that Sug1 is important for the transcription of
K Akiyama et al.
FEBS letters, 363(1-2), 151-156 (1995-04-17)
The nucleotide sequence of a cDNA that encodes a new regulatory subunit, named p45, of the 26S proteasome of human hepatoblastoma HepG2 cells has been determined. The polypeptide predicted from the open reading frame consists of 406 amino acid residues

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