H0500

1,2,3,4-Tetrahydroharmane-3-carboxylic acid

• Synonym(s): 1-Methyl-1,2,3,4-Tetrahydropyrido[3,4-b]indole-3-carboxylic acid, 1-Methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid, NSC 26225
• Empirical Formula (Hill Notation): C₁₃H₁₄N₂O₂
• CAS Number: 5470-37-1
• Molecular Weight: 230.26
• MDL number: MFCD00022199
• UNSPSC Code: 12352100
• PubChem Substance ID: 24895402
• NACRES: NA.22

Properties

• storage temp.: −20°C
• SMILES string: CC1NC(Cc2c1[nH]c3ccccc23)C(O)=O
• InChI: 1S/C13H14N2O2/c1-7-12-9(6-11(14-7)13(16)17)8-4-2-3-5-10(8)15-12/h2-5,7,11,14-15H,6H2,1H3,(H,16,17)
• InChI key: ZUPHXNBLQCSEIA-UHFFFAOYSA-N

Description

Application

Reactant involved in synthesis of molecules for biological studies including:

• Cytotoxicity and insecticidal activities of harmine derivatives
• Isoquinolines, β-carbolines, and 3-deazapurines via oxidative decarboxylation
• Cytotoxic evaluation of 1,3-di- and 1,3,9-trisubstituted β-carbolines

Biochem/physiol Actions

Implicated in eosinophilia-myalgia syndrome associated with L-tryptophan ingestion.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)