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H135

Sigma-Aldrich

5-Hydroxydecanoic acid sodium salt

≥97% (HPLC)

Synonym(s):

5-hydroxydecanoate sodium salt

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About This Item

Empirical Formula (Hill Notation):
C10H19NaO3
CAS Number:
71186-53-3
Molecular Weight:
210.25
MDL number:
MFCD00153808
UNSPSC Code:
12352106
PubChem Substance ID:
24278479
NACRES:
NA.77

Quality Level

100

assay

≥97% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: 10 mg/mL, clear

SMILES string

[Na+].CCCCCC(O)CCCC([O-])=O

InChI

1S/C10H20O3.Na/c1-2-3-4-6-9(11)7-5-8-10(12)13;/h9,11H,2-8H2,1H3,(H,12,13);/q;+1/p-1

InChI key

YNAGNECWEKMWRM-UHFFFAOYSA-M

Biochem/physiol Actions

Blocks post-ischemic actions of the K+ channel activator cromakalim.

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Caution

Hygroscopic

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Pinkee Phukon et al.
Biotechnology letters, 35(4), 607-611 (2012-12-25)
Using a new isolate of Pseudomonas aeruginosa, we obtained 7 g cell dry wt (CDW/l) using 5 % (w/v) glucose. Crude polyhydroxyalkanoates were obtained at 14.6 % of CDW. FTIR and NMR analysis confirmed that this was a new co-polymer:
Germán A Colareda et al.
The Journal of pharmacy and pharmacology, 70(9), 1174-1187 (2018-06-23)
Low-flow ischemia (LFI) is consequent to coronary disease and produces cardiac stunning during reperfusion (R). Energetic performance and mechanisms of Ca2+ handling during LFI/R are not known. Moreover, cardioprotection of the phytoestrogen genistein (Gen) remains to be demonstrated in LFI/R.
Asger Andersen et al.
Cardiology, 123(3), 177-180 (2012-11-07)
We investigated whether ischemic preconditioning (IPC) protects the right ventricular (RV) myocardium against ischemic injury in hearts treated with the specific mitochondrial ATP-sensitive potassium (K(ATP)) channel blocker 5-hydroxydecanoate (5-HD). Hearts from male Wistar rats (300 g, n = 39) were
Samy Talha et al.
Journal of applied physiology (Bethesda, Md. : 1985), 114(2), 172-179 (2012-10-30)
Brain natriuretic peptide (BNP) reduces the extent of myocardial infarction. We aimed to determine whether BNP may reduce skeletal muscle mitochondrial dysfunctions and oxidative stress through mitochondrial K(ATP) (mK(ATP)) channel opening after ischemia-reperfusion (IR). Wistar rats were assigned to four
G J Grover et al.
Journal of cardiovascular pharmacology, 16(6), 853-864 (1990-12-01)
The detailed antiischemic pharmacology of the potassium channel activator cromakalim was determined in isolated globally ischemic rat hearts and a canine model of coronary occlusion and reperfusion. Cromakalim significantly improved reperfusion function in rat hearts starting at a concentration of
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