H2663
Anti-Histone Deacetylase 2 (HDAC2) antibody, Mouse monoclonal
clone HDAC2-62, purified from hybridoma cell culture
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About This Item
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biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
HDAC2-62, monoclonal
form
buffered aqueous solution
mol wt
antigen ~55 kDa
species reactivity
human, chicken, bovine, canine, rat, mouse
packaging
antibody small pack of 25 μL
General description
Anti-Histone Deacetylase 2 (HDAC2) antibody, Mouse monoclonal (mouse IgG2b isotype) is derived from the HDAC2-62 hybridoma produced by the fusion of mouse myeloma cells (NS1) and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to the C-terminal region of human histone deacetylase 2 (amino acid residues with N-terminal added cysteine) conjugated to maleimide-activated KLH. Histone deacetylase 2 (HDAC2) is the catalytic subunits of different multiprotein regulatory complexes.
Specificity
Monoclonal Anti-Histone Deacetylase 2 (HDAC2) recognizes human, bovine, dog, rat, mouse, and chicken HDAC2 (approx. 55 kDa). The antibody epitope resides within amino acids 471-488 of human HDAC2.
application
Anti-Histone Deacetylase 2 (HDAC2) antibody, Mouse monoclonal has been used in:
- co-immunoprecipitation
- chromatin immunoprecipitation (ChIP)
- western blot
- immunohistochemistry
- enzyme linked immunosorbent assays (ELISA)
Biochem/physiol Actions
Histone Deacetylases including HDAC′s 1-10 facilitate transcriptional repression and nucleosome condensation. Abnormal recruitment of HDACs by various oncoproteins may occur in certain neoplastic diseases. Inhibition of HDAC2 activity by valproic acid induces proteasomal degradation of HDAC2.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, and 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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HDAC2 Inhibitor Valproic Acid Increases Radiation Sensitivity of Drug-Resistant Melanoma Cells
Kalal BS, et al.
Medical sciences (Basel, Switzerland), 7 (2019)
Christi Cho et al.
International journal of molecular sciences, 23(3) (2022-02-16)
Epilepsy is a heterogenous neurological disorder characterized by recurrent unprovoked seizures, mitochondrial stress, and neurodegeneration. Hydrogen sulfide (H2S) is a gasotransmitter that promotes mitochondrial function and biogenesis, elicits neuromodulation and neuroprotection, and may acutely suppress seizures. A major gap in
Histone Deacetylases: A Saga of Perturbed Acetylation Homeostasis in Cancer
Parbin S, et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 62 (2014)
Combined HDAC1 and HDAC2 Depletion Promotes Retinal Ganglion Cell Survival After Injury Through Reduction of p53 Target Gene Expression
Lebrun-Julien F and Suter U
ASN Neuro, 7 (2015)
Stem Cell Factor SALL4 Represses the Transcriptions of PTEN and SALL1 through an Epigenetic Repressor Complex
Lu J, et al.
PLoS ONE, 4 (2009)
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