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H4415

Sigma-Aldrich

HC-030031

≥98% (HPLC), powder

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Synonym(s):
1,2,3,6-Tetrahydro-1,3-dimethyl-N-[4-(1-methylethyl)phenyl]-2,6-dioxo-7H-purine-7-acetamide, 2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide
Empirical Formula (Hill Notation):
C18H21N5O3
CAS Number:
Molecular Weight:
355.39
MDL number:
PubChem Substance ID:
NACRES:
NA.25

Quality Level

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL, clear

storage temp.

room temp

SMILES string

CC(C)c1ccc(NC(=O)Cn2cnc3N(C)C(=O)N(C)C(=O)c23)cc1

InChI

1S/C18H21N5O3/c1-11(2)12-5-7-13(8-6-12)20-14(24)9-23-10-19-16-15(23)17(25)22(4)18(26)21(16)3/h5-8,10-11H,9H2,1-4H3,(H,20,24)

InChI key

HEQDZPHDVAOBLN-UHFFFAOYSA-N

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This Item
SML1142SML1781SML0803
HC-030031 ≥98% (HPLC), powder

H4415

HC-030031

VU0071063 ≥98% (HPLC)

SML1142

VU0071063

PDD00017273 ≥98% (HPLC)

SML1781

PDD00017273

Sigma-Aldrich

SML0803

VUF10661

form

powder

form

powder

form

powder

form

powder

storage temp.

room temp

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

solubility

DMSO: 10 mg/mL, clear

solubility

DMSO: 10 mg/mL, clear

solubility

DMSO: 10 mg/mL, clear

solubility

DMSO: 10 mg/mL, clear

color

white to beige

color

white to beige

color

white to beige

color

white to beige

Biochem/physiol Actions

HC-030031 is a selective TRPA1 channel blocker, antagonizing formalin-evoked calcium influx and formalin-induced pain. IC50 is 5 μM. TRPA1 antagonism is a promising therapeutic target for chronic inflammatory or neurogenic pain.
HC-030031 is a selective TRPA1 channel blocker. HC-030031 antagonizes formalin-evoked calcium influx. IC50 is 5 μM.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges


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Luana Fischer et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 66(4), 311-322 (2016-12-03)
Although TRPA1, SP, histamine and 5-hydroxytryptamine (5-HT) have recognized contribution to nociceptive mechanisms, little is known about how they interact with each other to mediate inflammatory pain in vivo. In this study we evaluated whether TRPA1, SP, histamine and 5-HT
Coline Legrand et al.
Scientific reports, 10(1), 11238-11238 (2020-07-10)
The transient receptor potential (TRP) channels family are cationic channels involved in various physiological processes as pain, inflammation, metabolism, swallowing function, gut motility, thermoregulation or adipogenesis. In the oral cavity, TRP channels are involved in chemesthesis, the sensory chemical transduction
Yan Xu et al.
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 29(6), 692-700 (2018-11-02)
Transient receptor potential ankyrin 1 (TRPA1) and substance P (SP), both expression in sensory neurons, have important roles in stress-induced duodenal lesions. The possible contribution of TRPA1 and SP to stress-induced duodenal lesions was explored by using the water immersion
Florian Schillers et al.
The Journal of pharmacology and experimental therapeutics, 359(1), 18-25 (2016-07-28)
Propacetamol (PPCM) is a prodrug of paracetamol (PCM), which was generated to increase water solubility of PCM for intravenous delivery. PPCM is rapidly hydrolyzed by plasma esterases to PCM and diethylglycine and shares some structural and metabolic properties with lidocaine.
Anthony Bosson et al.
Molecular neurodegeneration, 12(1), 53-53 (2017-07-08)
Excessive synaptic loss is thought to be one of the earliest events in Alzheimer's disease (AD). However, the key mechanisms that maintain plasticity of synapses during adulthood or initiate synapse dysfunction in AD remain unknown. Recent studies suggest that astrocytes

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