I0160

Imipenem monohydrate

≥98% (HPLC), B-lactam antibiotic, powder

• Synonym(s): (5R,6S)-6-[(1R)-1-Hydroxyethyl]-3-[[2-[(iminomethyl)amino]ethyl]thio]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid monohydrate, Primaxin monohydrate, Tienam monohydrate
• Empirical Formula (Hill Notation): C₁₂H₁₇N₃O₄S · H₂O
• CAS Number: 74431-23-5
• Molecular Weight: 317.36
• NACRES: NA.77
• PubChem Substance ID: 329815301
• UNSPSC Code: 12352200
• EC Number: 264-734-5
• MDL number: MFCD09753321
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Product Name: Imipenem monohydrate, ≥98% (HPLC)
• assay: ≥98% (HPLC)
• form: powder
• antibiotic activity spectrum: mycobacteria
• mode of action: cell wall synthesis | interferes
• originator: Merck & Co., Inc., Kenilworth, NJ, U.S.
• storage temp.: −20°C
• SMILES string: O.C[C@@H](O)[C@@H]1[C@H]2CC(SCCNC=N)=C(N2C1=O)C(O)=O
• InChI: 1S/C12H17N3O4S.H2O/c1-6(16)9-7-4-8(20-3-2-14-5-13)10(12(18)19)15(7)11(9)17;/h5-7,9,16H,2-4H2,1H3,(H2,13,14)(H,18,19);1H2/t6-,7-,9-;/m1./s1
• InChI key: GSOSVVULSKVSLQ-JJVRHELESA-N

Description

General description

Chemical structure: β-lactam

Application

Imipenem monohydrate has been used to determine the resistance profiles of Pseudomonas aeruginosa isolates. It has also been used in susceptibility testing against Acinetobacter baumannii.

Biochem/physiol Actions

Imipenem is found effective against gram positive and negative aerobes and anaerobes. Imipenem is often combined with cilastatin, to inhibit its metabolism in kidney.

Imipenem monohydrate is a broad spectrum B-lactam antibiotic.

Imipenem monohydrate is a broad spectrum B-lactam antibiotic. It is a member of the carbapenem class of "magic bullet" antibiotics for severe infections.

Features and Benefits

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• Storage Class: 11 - Combustible Solids
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)