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I0759

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Anti-Human IgM (μ-chain specific) antibody produced in goat

affinity isolated antibody, lyophilized powder

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Synonym(s):
Anti Human IgM Antibody - Anti-Human IgM (μ-chain specific) antibody produced in goat, Anti Human Igm, Anti Human Igm Antibody, Anti-Human Igm
MDL number:
NACRES:
NA.46

biological source

goat

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

secondary antibodies

clone

polyclonal

form

lyophilized powder

technique(s)

Ouchterlony double diffusion: suitable
quantitative precipitin assay: suitable

storage temp.

2-8°C

target post-translational modification

unmodified

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This Item
A9935A6907I0884
technique(s)

Ouchterlony double diffusion: suitable, quantitative precipitin assay: suitable

technique(s)

Ouchterlony double diffusion: suitable, immunoelectrophoresis: suitable

technique(s)

direct ELISA: 1:10,000

technique(s)

Ouchterlony double diffusion: suitable

biological source

goat

biological source

goat

biological source

goat

biological source

goat

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

clone

polyclonal

clone

polyclonal

clone

polyclonal

clone

polyclonal

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General description

Human serum-derived IgM may be used as a reference antigen, standard, blocking agent, or coating protein in a variety of immunoassays including ELISA, dot immunobinding, Western immunoblotting, immunodiffusion, and immunoelectrophoresis. Other applications include starting materials for the preparation of immunogens and solid phase immunoadsorbents.
Immunoglobulin M (IgM) antibodies appear early in the course of infections. IgM antibodies are responsible for agglutination of red blood cells in mis-matched blood transfusions. The level of IgM may vary with the status of disease or infection.
IgM antibodies are present as pentamers in the serum and are produced in response to antigens
Anti-Human IgM (μ-chain specific) antibody is specific for human IgM with mu chain. The antibody preparation is specific for human IgM when tested against purified human IgA, IgG, IgM, Bence Jones κ and Bence Jones λ myeloma proteins.

Specificity

Goat polyclonal Anti-Human IgM (μ-chain specific) antibody reacts with the m-chain of human IgM. It is specific for human IgM when tested against purified human IgA, IgG, IgM, Bence Jones kappa and Bence Jones lambda myeloma proteins.

Immunogen

Purified human IgM as immunogen

Application

Anti-Human IgM (μ-chain specific) antibody is suitable for Ouchterlony double diffusion and quantitative precipitin assay. It was used in B-cell receptor cross-linking studies, AuBioDOT assays, ELISA, protein purification and gel blot analysis.
Goat polyclonal Anti-Human IgM (μ-chain specific) antibody may be used to identify and quantitate the level of human IgM in vitro and in human serum or other biological fluids by immunochemical or immunohistological techniques.

Physical form

Lyophilized from 0.01 M sodium phosphate, 0.015 M sodium chloride, pH 7.2

Reconstitution

Reconstitute with 0.135 M sodium chloride.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Harini Natarajan et al.
BMC immunology, 23(1), 7-7 (2022-02-18)
While antibodies can provide significant protection from SARS-CoV-2 infection and disease sequelae, the specific attributes of the humoral response that contribute to immunity are incompletely defined. We employ machine learning to relate characteristics of the polyclonal antibody response raised by
Susana Vázquez et al.
Clinical and diagnostic laboratory immunology, 10(6), 1074-1077 (2003-11-11)
The Dengue IgM Capture ELISA (MAC-ELISA) is the immunoenzymatic system recommended by the Pan American Health Organization and the World Health Organization for the serological diagnosis of dengue virus infection due to its high sensitivity, ease of performance, and use
Whitney Bullard et al.
Virulence, 3(1), 72-76 (2012-01-31)
The haptoglobin-hemoglobin receptor (HpHbR) of African trypanosomes plays a critical role in human innate immunity against these parasites. Localized to the flagellar pocket of the veterinary pathogen Trypanosoma brucei brucei this receptor binds Trypanosome Lytic Factor-1 (TLF-1), a subclass of
John G Kosowicz et al.
Journal of virology, 91(16) (2017-06-02)
Epstein-Barr virus (EBV) is a ubiquitous human gammaherpesvirus that establishes a latency reservoir in B cells. In this work, we show that ibrutinib, idelalisib, and dasatinib, drugs that block B cell receptor (BCR) signaling and are used in the treatment
Zhen Lin et al.
Journal of virology, 90(7), 3469-3479 (2016-01-15)
In the oral epithelium, peripheral stores of Epstein-Barr virus (EBV) are transmitted from infiltrating B cells to epithelial cells. Once the virus is transmitted to epithelial cells, the highly permissive nature of this cell type for lytic replication allows virus

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