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J4455

Sigma-Aldrich

JSH-23

≥98% (HPLC), solid

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Synonym(s):
4-methyl-N1-(3-phenylpropyl)-1,2-benzenediamine
Empirical Formula (Hill Notation):
C16H20N2
CAS Number:
Molecular Weight:
240.34
NACRES:
NA.77

Quality Level

assay

≥98% (HPLC)

form

solid

storage condition

protect from light

color

off-white to gray-pink

solubility

DMSO: >10 mg/mL

shipped in

wet ice

storage temp.

−20°C

InChI

1S/C16H20N2/c1-13-9-10-16(15(17)12-13)18-11-5-8-14-6-3-2-4-7-14/h2-4,6-7,9-10,12,18H,5,8,11,17H2,1H3

InChI key

YMFNPBSZFWXMAD-UHFFFAOYSA-N

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This Item
S5192SML1555SML2534
JSH-23 ≥98% (HPLC), solid

J4455

JSH-23

SB 222200 ≥98% (HPLC), solid

S5192

SB 222200

MS023 hydrochloride ≥98% (HPLC)

SML1555

MS023 hydrochloride

DJ-V-159 ≥98% (HPLC)

SML2534

DJ-V-159

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

-

Quality Level

100

Quality Level

-

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

solubility

DMSO: >10 mg/mL

solubility

DMSO: soluble ~28 mg/mL, H2O: insoluble

solubility

H2O: 20 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

storage condition

protect from light

storage condition

-

storage condition

desiccated

storage condition

-

Application

JSH-23 has been used as a nuclear factor κB (NF-κB) p65 inhibitor.

Biochem/physiol Actions

JSH-23 is an inhibitor of NF-kB nuclear translocation. It inhibits LPS and cytokine-induced nuclear translocation of the p65 subunit of NF-kB as analyzed by EMSA and western blot. The compound displays modest potency (IC50 7.1 uM in RAW 264.7), but has the unique property that it does not affect IkB degradation or recovery. The compound dose dependently inhibits LPS induced expression of cytokines, COX2 and iNOS, and presumably binds to, or interferes with the NLS of p65.

Other Notes

Light and air sensitive.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3


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