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L7022

Sigma-Aldrich

Sodium L-lactate

~98%

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Synonym(s):
(S)-2-Hydroxypropionic acid sodium salt, L-Lactic acid sodium salt, Sarcolactic acid sodium salt
Empirical Formula (Hill Notation):
C3H5NaO3
CAS Number:
Molecular Weight:
112.06
Beilstein/REAXYS Number:
4567087
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.25

assay

~98%

Quality Level

form

powder or crystals

mp

163-165 °C (lit.)

storage temp.

2-8°C

SMILES string

[Na+].C[C@H](O)C([O-])=O

InChI

1S/C3H6O3.Na/c1-2(4)3(5)6;/h2,4H,1H3,(H,5,6);/q;+1/p-1/t2-;/m0./s1

InChI key

NGSFWBMYFKHRBD-DKWTVANSSA-M

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1 of 4

This Item
71720161430871716
vibrant-m

L7022

Sodium L-lactate

vibrant-m

71720

Sodium DL-lactate

vibrant-m

1614308

Sodium lactate

vibrant-m

71716

Sodium D-lactate

Quality Level

200

Quality Level

200

Quality Level

-

Quality Level

100

mp

163-165 °C (lit.)

mp

-

mp

163-165 °C (lit.)

mp

-

form

powder or crystals

form

powder

form

-

form

powder

storage temp.

2-8°C

storage temp.

-

storage temp.

2-8°C

storage temp.

-

General description

Sodium L-lactate, an organic acid derived from L-lactic acid, naturally occurs in the body, contributing to pH regulation, acid-base equilibrium, and various physiological processes, including energy metabolism through the Cori cycle. Its versatile properties extend to antimicrobial action by creating an acidic environment that inhibits harmful bacterial growth. In metabolic pathways, Sodium L-lactate exhibits efficient conversion for energy production, potentially surpassing glucose uptake in certain instances, utilizing fatty acids as an alternative fuel source, and stimulating mitochondria for enhanced ATP production, indicating a role in optimizing cellular energy efficiency. Moreover, research suggests neuroprotective capabilities, safeguarding neuronal cells from high-fat diet-induced death and addressing potential links to obesity-related neurodegenerative issues.

This multifaceted nature of Sodium L-lactate positions it as a valuable molecule for research in cellular metabolism, neuroprotection, antimicrobial, and nutritional science, where its diverse properties, including efficient energy conversion, neuroprotective effects, and potent antimicrobial activity contribute to a deeper understanding across these scientific domains.

Application

Sodium L-lactate has been used:
  • as a medium supplement and cell fuel source for human mammary epithelial cell line(MCF10A) and dendritic cell culture
  • as a gluconeogenic substrate in hepatic glucose production assay in primary hepatocytes
  • in the glucose production medium for glucose production assay in human embryonic kidney (HEK293T) cells
  • as a standard for calibration in lactate assay in bone marrow-derived macrophages

Biochem/physiol Actions

L-lactate is produced from pyruvate by the enzyme lactate dehydrogenase. Lactate production occurs during anaerobic glycolysis or in proliferatively active cells.

Features and Benefits

Versatile and adaptable for a wide variety of laboratory and research applications

Other Notes

For additional information on our range of Biochemicals, please complete this form.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Articles

Sigma-Aldrich presents an article about how proliferatively active cells require both a source of carbon and of nitrogen for the synthesis of macromolecules. Although a large proportion of tumor cells utilize aerobic glycolysis and shunt metabolites away from mitochondrial oxidative phosphorylation, many tumor cells exhibit increased mitochondrial activity.

We presents an article about the Warburg effect, and how it is the enhanced conversion of glucose to lactate observed in tumor cells, even in the presence of normal levels of oxygen. Otto Heinrich Warburg demonstrated in 1924 that cancer cells show an increased dependence on glycolysis to meet their energy needs, regardless of whether they were well-oxygenated or not.

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