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M1523

Sigma-Aldrich

Muscimol

powder

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Synonym(s):
3-Hydroxy-5-aminomethyl-isoxazole, 5-Aminomethyl-3-hydroxy-isoxazole, 5-Aminomethyl-3-isoxazolol, Agarine, Pantherine
Empirical Formula (Hill Notation):
C4H6N2O2
CAS Number:
Molecular Weight:
114.10
Beilstein:
1618960
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.77

form

powder

Quality Level

color

white to off-white

storage temp.

2-8°C

SMILES string

NCC1=CC(=O)NO1

InChI

1S/C4H6N2O2/c5-2-3-1-4(7)6-8-3/h1H,2,5H2,(H,6,7)

InChI key

ZJQHPWUVQPJPQT-UHFFFAOYSA-N

Gene Information

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This Item
H9523P9158PHL89495
Muscimol powder

Sigma-Aldrich

M1523

Muscimol

Muscimol phyproof® Reference Substance

PHL89495

Muscimol

color

white to off-white

color

white to off-white

color

white to off-white

color

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

Quality Level

200

Quality Level

-

Quality Level

-

Quality Level

-

Gene Information

rat ... Gabra2(29706)

Gene Information

human ... HTR3A(3359)

Gene Information

-

Gene Information

-

General description

Muscimol is a psychoactive isoxazole component, which is found in Amanita muscaria and related mushrooms. It lowers cerebral glucose metabolism and increases the level of 5-hydroxytryptamine in brain. Muscimol has hallucinogenic effects. It is associated with distorted perceptions, nausea and vomiting.

Application

Muscimol has been used:
  • to reduce conditioned fear-expression in lateral amygdala (LA)
  • to eliminate cortical cell response in ferrets
  • to inactivate lateral magnocellular nucleus of the nidopallium (LMAN) in zebra finches

Biochem/physiol Actions

GABAA receptor agonist.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the GABAA Receptors and GABAC Receptors pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictograms

Skull and crossbones

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 2 Oral - STOT SE 3

Target Organs

Central nervous system

Storage Class Code

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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705578-5MG-PW

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