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M1568

Sigma-Aldrich

Mannose triflate

For PET imaging, ≥98% (TLC)

Synonym(s):

β-D-Mannopyranose 1,3,4,6-tetra-O-acetate 2-O-trifluoromethanesulfonate, 1,3,4,6-Tetra-O-acetyl-2-O-trifluoromethanesulfonyl-β-D-mannopyranose, Mannose triflate, TATM

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500 ML
$215.00

$215.00

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500 ML
$215.00

About This Item

Empirical Formula (Hill Notation):
C15H19F3O12S
CAS Number:
92051-23-5
Molecular Weight:
480.36
Beilstein/REAXYS Number:
4341413
MDL number:
MFCD00012353
UNSPSC Code:
41116107
PubChem Substance ID:
24896669
NACRES:
NA.12

$215.00

In StockDetails

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Quality Level

200

assay

≥98% (TLC)

form

powder

technique(s)

PET imaging: suitable

shipped in

dry ice

storage temp.

−20°C

SMILES string

CC(=O)OC[C@H]1O[C@@H](OC(C)=O)[C@@H](OS(=O)(=O)C(F)(F)F)[C@@H](OC(C)=O)[C@@H]1OC(C)=O

InChI

1S/C15H19F3O12S/c1-6(19)25-5-10-11(26-7(2)20)12(27-8(3)21)13(14(29-10)28-9(4)22)30-31(23,24)15(16,17)18/h10-14H,5H2,1-4H3/t10-,11-,12+,13+,14-/m1/s1

InChI key

OIBDVHSTOUGZTJ-PEBLQZBPSA-N

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L-WBRABWASH4H5413
HIS-Select® Wash Buffer

H5288

HIS-Select® Wash Buffer

Millipore

L-WB

10X Wash Buffer

20X Wash Buffer (Item B)

RABWASH4

20X Wash Buffer (Item B)

HIS-Select® Elution Buffer

H5413

HIS-Select® Elution Buffer

General description

Mannose triflate is a glucose analogue.

Application

Mannose triflate is a well-known precursor for 18F-FDG synthesis for PET applications. The binding of 18F to the mannose triflate has been carried out via SN2 nucleophilic substitution reaction. It is used in computational tomography, an imaging technique in early detection of cancer.

Other Notes

This formulation of mannose triflate has reduced trace impurities that are known to cause lower synthetic yields.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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    Certificates of Analysis (COA)

    Lot/Batch Number
    0000417282
    0000417283
    0000419879
    0000419394
    0000419880

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    Gulcan Unak et al.
    Colloids and surfaces. B, Biointerfaces, 90, 217-226 (2011-11-11)
    A new architecture has been designed by the conjugation of [(18)F]2-fluoro-2-deoxy-D-glucose ((18)F-FDG), gold nanoparticles (AuNPs), and anti-metadherin (Anti-MTDH) antibody which is specific to the metadherin (MTDH) over-expressed on the surface of breast cancer cells. Mannose triflate molecule is used as
    Ren Iwata et al.
    Journal of labelled compounds & radiopharmaceuticals, 61(7), 540-549 (2018-03-10)
    High specific activity is often a significant requirement for radiopharmaceuticals. To achieve that with fluorine-18 (18 F)-labeled probes, it is mandatory to start from no-carrier-added fluoride and to reduce to a minimum the amount of precursor in order to decrease
    Shane B Claggett et al.
    EJNMMI research, 3(1), 53-53 (2013-07-17)
    Many automated radiosynthesizers for producing positron emission tomography (PET) probes provide a means for the operator to create custom synthesis programs. The programming interfaces are typically designed with the engineer rather than the radiochemist in mind, requiring lengthy programs to
    Padgett, H., et al.
    Applied Radiation and Isotopes, 40, 433-433 (1989)
    Martin Thunemann et al.
    Nature communications, 8(1), 444-444 (2017-09-07)
    Many pathophysiological processes are associated with proliferation, migration or death of distinct cell populations. Monitoring specific cell types and their progeny in a non-invasive, longitudinal and quantitative manner is still challenging. Here we show a novel cell-tracking system that combines
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