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Key Documents

COO/COA

N0659

Noxiustoxin

Name: Noxiustoxin
Brand: SIGMA

≥95% (HPLC), recombinant, expressed in E. coli, lyophilized powder

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About This Item

MDL number:

MFCD00241268

UNSPSC Code:

12352200

recombinant

expressed in E. coli

assay

≥95% (HPLC)

form

lyophilized powder

mol wt

4195 Da

storage temp.

−20°C

Biochem/physiol Actions

Blocks voltage-gated potassium channels.

Other Notes

Originally isolated from Heteropoda venatoria

Reconstitution

Solubilize in 10 mM Tris, pH 7.5, containing 100 mM sodium chloride, 0.1% bovine serum albumin, and 1 mM EDTA

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines.

S Grissmer et al.

Molecular pharmacology, 45(6), 1227-1234 (1994-06-01)

We have analyzed the biophysical and pharmacological properties of five cloned K+ (Kv) channels (Kv1.1, Kv1.2, Kv1.3, Kv1.5, and Kv3.1) stably expressed in mammalian cell lines. Kv1.1 is biophysically similar to a K+ channel in C6 glioma cells and astrocytes

Chemical synthesis, structural and functional characterisation of noxiustoxin, a powerful blocker of lymphocyte voltage-dependent K+ channels.

E Drakopoulou et al.

Biochemical and biophysical research communications, 213(3), 901-907 (1995-08-24)

Two forms of the Centrudoides noxius scorpion noxiustoxin, containing an amidated and an acid C-terminus, were synthesized on a solid support by using Fmoc-chemistry and 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate (HBTU) coupling. Comparison of the two synthetic forms with the native toxin by

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